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Title

A 6-week supplementation with grape pomace to subjects at cardiometabolic risk ameliorates insulin sensitivity, without affecting other metabolic syndrome markers

AuthorsMartínez-Maqueda, D. ; Zapatera, Belén ; Gallego-Narbón, Angélica; Vaquero, M. Pilar ; Saura Calixto, Fulgencio D. ; Pérez-Jiménez, Jara
Issue Date2018
PublisherRoyal Society of Chemistry (UK)
CitationFood & function 9: 6010-6019 (2018)
AbstractGrape polyphenols have shown a promising role in the modulation of metabolic syndrome (MetS), mostly in animal models. However, clinical studies are scarce and they usually only consider a fraction of polyphenols, ignoring the non-extractable polyphenols (high molecular weight compounds or associated with macromolecules such as dietary fibre). This study aimed at evaluating the effect of grape pomace, rich in both extractable and non-extractable polyphenols, on markers of MetS. Fifty subjects (22 women) aged 20–65 with at least two MetS factors were randomly assigned to the product (daily dose of 8 g of dried grape pomace) or to the control group in a 6 week crossover design with a 4 week wash-out. Samples were collected at the beginning and at the end of both periods; half of the participants were subjected to an oral glucose tolerance test at the beginning and the end of the supplementation period. Grape pomace supplementation significantly improved fasting insulinaemia (p < 0.01), without affecting other cardiometabolic risk parameters. A tendency towards an improvement in postprandial insulinaemia was observed, particularly in those subjects with higher fasting insulin levels. Therefore, supplementation with grape pomace may be a strategy for improving insulin sensitivity in subjects at high cardiometabolic risk.
Publisher version (URL)http://dx.doi.org/10.1039/C8FO01323C
URIhttp://hdl.handle.net/10261/217086
Identifiersdoi: 10.1039/C8FO01323C
e-issn: 2042-650X
issn: 2042-6496
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