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Title

A vaccinology approach to the identification and characterization of Dermanyssus gallinae candidate protective antigens for the control of poultry red mite infestations

AuthorsLima-Barbero, José Francisco; Contreras, Marinela; Mateos-Hernández, Lourdes ; Mata-Lorenzo, Francisco Manuel; Triguero, Roxana; Sparagano, Olivier; Finn, Robert D.; Strube, Chrisina; Price, Daniel R.G.; Nunn, Francesca; Bartley, Kathryn; Höfle, Ursula ; Boadella, Mariana ; Nisbet, Alasdair J.; Fuente, José de la ; Villar, Margarita
KeywordsDermanyssus
Poultry red mite
Proteomics
Vaccine
Vaccinology
Protective antigens
Issue Date2019
PublisherMultidisciplinary Digital Publishing Institute
CitationVaccines 7(4): 190 (2019)
AbstractThe poultry red mite (PRM), Dermanyssus gallinae, is a hematophagous ectoparasite considered as the major pest in the egg-laying industry. Its pesticide-based control is only partially successful and requires the development of new control interventions such as vaccines. In this study, we follow a vaccinology approach to identify PRM candidate protective antigens. Based on proteomic data from fed and unfed nymph and adult mites, we selected a novel PRM protein, calumenin (Deg-CALU), which is tested as a vaccine candidate on an on-hen trial. Rhipicephalus microplus Subolesin (Rhm-SUB) was chosen as a positive control. Deg-CALU and Rhm-SUB reduced the mite oviposition by 35 and 44%, respectively. These results support Deg-CALU and Rhm-SUB as candidate protective antigens for the PRM control.
Publisher version (URL)https://doi.org/10.3390/vaccines7040190
URIhttp://hdl.handle.net/10261/215379
DOI10.3390/vaccines7040190
E-ISSN2076-393X
Appears in Collections:(IREC) Artículos
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