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Título: | Proteins and microRNAs are differentially expressed in tear fluid from patients with Alzheimer's disease |
Autor: | Kenny, Aidan; Jiménez-Mateos, Eva María; Zea-Sevilla, María Ascensión; Rábano, Alberto; Gili-Manzanaro, Pablo; Prehn, Jochen H. M.; Henshall, David C.; Ávila, Jesús CSIC ORCID ; Engel, Tobías; Hernández, Félix | Fecha de publicación: | 2019 | Editor: | Springer Nature | Citación: | Scientific Reports 9 (2019) | Resumen: | Alzheimer¿s disease (AD) is cha racterized by a progressive loss of neurons and cognitive functions. Therefore, early diagnosis of AD is critical. The development of practical and non-invasive diagnostic tests for AD remains, however, an unmet need. In the present proof-of-concept study we investigated tear fuid as a novel source of disease-specifc protein and microRNA-based biomarkers for AD development using samples from patients with mild cognitive impairment (MCI) and AD. Tear protein content was evaluated via liquid chromatography-mass spectrometry and microRNA content was profled using a genome-wide high-throughput PCR-based platform. These complementary approaches identifed enrichment of specifc proteins and microRNAs in tear fuid of AD patients. In particular, we identifed elongation initiation factor 4E (eIF4E) as a unique protein present only in AD samples. Total microRNA abundance was found to be higher in tears from AD patients. Among individual microRNAs, microRNA-200b-5p was identifed as a potential biomarker for AD with elevated levels present in AD tear fuid samples compared to controls. Our study suggests that tears may be a useful novel source of biomarkers for AD and that the identifcation and verifcation of biomarkers within tears may allow for the development of a non-invasive and cost-efective diagnostic test for AD | URI: | http://hdl.handle.net/10261/215292 | Identificadores: | issn: 2045-2322 |
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