Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/215078
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Novel association of five HLA alleles with HIV-1 progression in Spanish long-term non progressor patients |
Autor: | Ramírez de Arellano, Eva; Díez-Fuertes, Francisco; Aguilar, Francisco; Erick de la Torre Tarazona, Humberto; Sánchez-Lara, Susana; Laó, Yolanda; Vicario, José Luis; García, Felipe; González-García, Juan; Pulido, Federico; Gutierrrez-Rodero, Félix; Moreno, Santiago; Iribarren, José Antonio; Viciana, Pompeyo CSIC; Vilches, Carlos; Ramos, Manuel CSIC ORCID; Capa, Laura; Alcamí, José CSIC ORCID; Val, Margarita del CSIC ORCID | Fecha de publicación: | 8-ago-2019 | Editor: | Public Library of Science | Citación: | PLoS ONE 14 (2019) | Resumen: | Certain host genetic variants, especially in the human leucocyte antigen (HLA) region, are associated with different progression of HIV-1-induced diseases and AIDS. Long term non progressors (LTNP) represent only the 2% of infected patients but are especially relevant because of their efficient HIV control. In this work we present a global analysis of genetic data in the large national multicenter cohort of Spanish LTNP, which is compared with sero-negative individuals and HIV-positive patients. We have analyzed whether several single-nucleotide polymorphisms (SNPs) including in key genes and certain HLA-A and B alleles could be associated with a specific HIV phenotype. A total of 846 individuals, 398 HIV-1positive patients (213 typical progressors, 55 AIDS patients, and 130 LTNPs) and 448 HIV-negative controls, were genotyped for 15 polymorphisms and HLA-A and B alleles. Significant differences in the allele frequencies among the studied populations identified 16 LTNP-associated genetic factors, 5 of which were defined for the first time as related to LTNP phenotype: the protective effect of HLA-B39, and the detrimental impact of HLA-B18, -A24, -B08 and –A29. The remaining eleven polymorphisms confirmed previous publications, including the protective alleles HLA-B57, rs2395029 (HCP5), HLA bw4 homozygosity, HLA-B52, HLA-B27, CCR2 V64I, rs9264942 (HLA-C) and HLA-A03; and the risk allele HLA bw6 homozygosity. Notably, individual Spanish HIV-negative individuals had an average of 0.12 protective HLA alleles and SNPs, compared with an average of 1.43 protective alleles per LTNP patient, strongly suggesting positive selection of LTNP. Finally, stratification of LTNP according to viral load showed a proportional relationship between the frequency of protective alleles with control of viral load. Interestingly, no differences in the frequency of protection/risk polymorphisms were found between elite controllers and LTNPs maintaining viral loads <2.000 copies/mL throughout the follow-up. | Versión del editor: | http://dx.doi.org/10.1371/journal.pone.0220459 | URI: | http://hdl.handle.net/10261/215078 | DOI: | 10.1371/journal.pone.0220459 | Identificadores: | doi: 10.1371/journal.pone.0220459 issn: 1932-6203 |
Aparece en las colecciones: | (CBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
ValMdel_NovelAssociationofFive.pdf | 1,09 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
7
checked on 20-abr-2024
SCOPUSTM
Citations
11
checked on 16-abr-2024
WEB OF SCIENCETM
Citations
11
checked on 27-feb-2024
Page view(s)
178
checked on 23-abr-2024
Download(s)
104
checked on 23-abr-2024