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Title

Spread of Streptococcus pneumoniae serotype 8-ST63 multidrug-resistant recombinant clone, Spain

AuthorsArdanuy, Carmen; Campa, Adela G. de la; García, Ernesto ; Fenoll, Asunción; Calatayud, Laura; Cercenado, Emilia; Perez-Trallero, Emilio; Bouza, Emilio; Liñares, Josefina
KeywordsStreptococcus pneumoniae
Bacteria
Antimicrobial resistance
Fluoroquinolone resistance
Sweden 15A-ST63 clone
Serotype 8-ST63
Dissemination
Spread
Spain
Issue DateNov-2014
CitationEmerg Infect Dis 20 (11) 1848-56 (2014)
AbstractSince 2004, a total of 131 isolates of Streptococcus pneumoniae multidrug-resistant invasive serotype 8 have been detected in Spain. These isolates showed resistance to erythromycin, clindamycin, tetracycline, and ciprofloxacin. All isolates were obtained from adult patients and shared a common genotype (sequence type [ST]63; penicillin-binding protein 1a [pbp1a], pbp2b, and pbp2x gene profiles; ermB and tetM genes; and a ParC-S79F change). Sixty-eight isolates that required a ciprofloxacin MIC ≥16 μg/mL had additional gyrA gene changes. Serotype 8-ST63 pbp2x sequences were identical with those of antimicrobial drug–susceptible serotype 8-ST53 isolates. Serotype 8-ST63 pbp2b sequences were identical with those of the multidrug-resistant Sweden 15A-ST63 clone. Recombination between the capsular locus and flanking regions of an ST53 isolate (donor) and an ST63 pneumococcus (recipient) generated the novel 15A-ST63 clone. One recombination point was upstream of pbp2x and another was within pbp1a. A serotype 8-ST63 clone was identified as a cause of invasive disease in Spain.
Description9 p.-4 fig.-1 tab.
Publisher version (URL)https://doi.org/10.3201/eid2011.131215
URIhttp://hdl.handle.net/10261/214766
DOI10.3201/eid2011.131215
ISSN1080-6040
E-ISSN1080-6059
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