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http://hdl.handle.net/10261/212348
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Nogales, Juan | - |
dc.contributor.author | Mueller, J. | - |
dc.contributor.author | Gudmundsson, S. | - |
dc.contributor.author | Canalejo, F. J. | - |
dc.contributor.author | Duque, Estrella | - |
dc.contributor.author | Monk, J | - |
dc.contributor.author | Feist, Adam M. | - |
dc.contributor.author | Ramos, Juan L. | - |
dc.contributor.author | Niu, W | - |
dc.contributor.author | Palsson, Bernhard Ø | - |
dc.date.accessioned | 2020-05-27T11:20:29Z | - |
dc.date.available | 2020-05-27T11:20:29Z | - |
dc.date.issued | 2020 | - |
dc.identifier | doi: 10.1111/1462-2920.14843 | - |
dc.identifier | issn: 1462-2920 | - |
dc.identifier.citation | Environmental Microbiology 22: 255- 269 (2020) | - |
dc.identifier.uri | http://hdl.handle.net/10261/212348 | - |
dc.description.abstract | Genome "scale reconstructions of metabolism are computational species" specific knowledge bases able to compute systemic metabolic properties. We present a comprehensive and validated reconstruction of the biotechnologically relevant bacterium Pseudomonas putida KT2440 that greatly expands computable predictions of its metabolic states. The reconstruction represents a significant reactome expansion over available reconstructed bacterial metabolic networks. Specifically, iJN1462 (i) incorporates several hundred additional genes and associated reactions resulting in new predictive capabilities, including new nutrients supporting growth; (ii) was validated by in vivo growth screens that included previously untested carbon (48) and nitrogen (41) sources; (iii) yielded gene essentiality predictions showing large accuracy when compared with a knock¿out library and Bar¿seq data; and (iv) allowed mapping of its network to 82 P. putida sequenced strains revealing functional core that reflect the large metabolic versatility of this species, including aromatic compounds derived from lignin. Thus, this study provides a thoroughly updated metabolic reconstruction and new computable phenotypes for P. putida, which can be leveraged as a first step toward understanding the pan metabolic capabilities of Pseudomonas. | - |
dc.description.sponsorship | H2020 Future and Emerging Technologies. Grant Number: 686585 H2020 LEIT Biotechnology. Grant Numbers: 635536, 814650 Ministerio de Economía y Competitividad. Grant Numbers: BIO2014‐59528‐JIN, RTI‐2018‐094370‐B‐I00 National Science Foundation Graduate Research Fellowship Program. Grant Number: 1610400 Novo Nordisk. Grant Number: NNF10CC1016517 U.S. Department of Energy. Grant Number: DE‐AC02‐05CH11231 | - |
dc.language | eng | - |
dc.publisher | Blackwell Publishing | - |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/686585 | - |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/635536 | - |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/814650 | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BIO2014-59528-JIN | - |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI-2018-094370-B-I00 | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.title | High-quality genome-scale metabolic modelling of Pseudomonas putida highlights its broad metabolic capabilities | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1111/1462-2920.14843 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1111/1462-2920.14843 | - |
dc.date.updated | 2020-05-27T11:20:29Z | - |
dc.rights.license | https://creativecommons.org/licenses/by-nc/4.0/ | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Novo Nordisk Foundation | - |
dc.contributor.funder | Department of Energy (US) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100000015 | es_ES |
dc.identifier.pmid | 31657101 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
Aparece en las colecciones: | (EEZ) Artículos |
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Fichero | Descripción | Tamaño | Formato | |
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2020_Nogales_EM_OA.pdf | 3,08 MB | Adobe PDF | Visualizar/Abrir |
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