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Título: | Antiproliferative activity of 2-alkyl-4-halopiperidines and 2-alkyl-4-halo-1,2,5,6-tetrahydropyridines in solid tumor cell lines |
Autor: | León, Leticia G.; Carballo, Rubén M.; Vega-Hernández, María C.; Martín, Víctor S. CSIC ORCID; Padrón, Juan I. CSIC ORCID ; Padrón, José M. | Palabras clave: | Marine drugs Anticancer drugs Halogenated piperidines Halogenated tetrahydropyridines Solid tumors Structure–activity relationship |
Fecha de publicación: | 17-may-2007 | Editor: | Elsevier | Citación: | Bioorganic and Medicinal Chemistry Letters 17(10): 2681-2684 (2007) | Resumen: | A series of trans-2-alkyl-4-halopiperidines and 2-alkyl-4-halo-1,2,5,6-tetrahydropyridines were prepared by means of an iron(III) catalyzed process. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780 (ovarian cancer), SW1573 (non-small cell lung cancer), and WiDr (colon cancer). The results on the biological activity revealed that, in general, the 2-alkyl-4-halo-1,2,5,6-tetrahydropyridine analogs are more potent than the trans-2-alkyl-4-halopiperidine derivatives. A remarkable selectivity of the aza compound 5f for the resistant cell line WiDr was observed. Cell cycle studies revealed a G2/M phase arrest for 5f. | Versión del editor: | https://doi.org/10.1016/j.bmcl.2007.03.010 | URI: | http://hdl.handle.net/10261/212239 | DOI: | 10.1016/j.bmcl.2007.03.010 | ISSN: | 0960-894X | E-ISSN: | 1464-3405 |
Aparece en las colecciones: | (IPNA) Artículos |
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