Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/212239
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Título

Antiproliferative activity of 2-alkyl-4-halopiperidines and 2-alkyl-4-halo-1,2,5,6-tetrahydropyridines in solid tumor cell lines

AutorLeón, Leticia G.; Carballo, Rubén M.; Vega-Hernández, María C.; Martín, Víctor S. CSIC ORCID; Padrón, Juan I. CSIC ORCID ; Padrón, José M.
Palabras claveMarine drugs
Anticancer drugs
Halogenated piperidines
Halogenated tetrahydropyridines
Solid tumors
Structure–activity relationship
Fecha de publicación17-may-2007
EditorElsevier
CitaciónBioorganic and Medicinal Chemistry Letters 17(10): 2681-2684 (2007)
ResumenA series of trans-2-alkyl-4-halopiperidines and 2-alkyl-4-halo-1,2,5,6-tetrahydropyridines were prepared by means of an iron(III) catalyzed process. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780 (ovarian cancer), SW1573 (non-small cell lung cancer), and WiDr (colon cancer). The results on the biological activity revealed that, in general, the 2-alkyl-4-halo-1,2,5,6-tetrahydropyridine analogs are more potent than the trans-2-alkyl-4-halopiperidine derivatives. A remarkable selectivity of the aza compound 5f for the resistant cell line WiDr was observed. Cell cycle studies revealed a G2/M phase arrest for 5f.
Versión del editorhttps://doi.org/10.1016/j.bmcl.2007.03.010
URIhttp://hdl.handle.net/10261/212239
DOI10.1016/j.bmcl.2007.03.010
ISSN0960-894X
E-ISSN1464-3405
Aparece en las colecciones: (IPNA) Artículos




Ficheros en este ítem:
Fichero Descripción Tamaño Formato
accesoRestringido.pdfArtículo principal16,34 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo

CORE Recommender

SCOPUSTM   
Citations

31
checked on 23-mar-2024

WEB OF SCIENCETM
Citations

27
checked on 26-feb-2024

Page view(s)

186
checked on 28-mar-2024

Download(s)

21
checked on 28-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


Este item está licenciado bajo una Licencia Creative Commons Creative Commons