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dc.contributor.authorMartínez, Rubénes_ES
dc.contributor.authorTu, Wenqinges_ES
dc.contributor.authorEng, Tyleres_ES
dc.contributor.authorAllaire-Leung, Melissaes_ES
dc.contributor.authorPiña, Benjamínes_ES
dc.contributor.authorNavarro-Martín, Laiaes_ES
dc.contributor.authorMennigen, Jan A.es_ES
dc.identifier.citationChemosphere 127080 (2020)es_ES
dc.description.abstractBisphenol A (BPA) is an estrogenic contaminant linked to metabolic disruption. Developmental BPA exposure is of particular concern, as organizational effects may irreversibly disrupt metabolism at later life-stages. While BPA exposures in adult fish elicit metabolic perturbations similar to effects described in rodents, the metabolic effects of developmental BPA exposure in juvenile fish remain largely unknown. Following embryonic zebrafish exposure to BPA (0.1, 1 and 4 mg/L) and EE2 (10 ng/L) from 2 to 5 dpf, we assessed the metabolic phenotype in larvae (4–6 dpf) and juveniles (43–49 dpf) which had been divided into regular-fed and overfed groups at 29 dpf. Developmental BPA exposure in larvae dose-dependently reduced food-intake and locomotion and increased energy expenditure. Juveniles (29 dpf) exhibited a transient increase in body weight after developmental BPA exposure and persistent diet-dependent locomotion changes (43–49 dpf). At the molecular level, glucose and lipid metabolism-related transcripts abundance clearly separated BPA exposed fish from controls and EE2 exposed fish at the larval stage, in juveniles on a regular diet and, to a lesser extent, in overfed juveniles. In general, the metabolic endpoints affected by BPA exposure were not mimicked by EE2 treatment. We conclude that developmental BPA exposure elicits acute metabolic effects in zebrafish larvae and fewer transient and persistent effects in juveniles and that these metabolic effects are largely independent of BPA's estrogenicity.es_ES
dc.description.sponsorshipThis work was supported by an NSERC-Discovery grant (#147476) and a Canadian Foundation for Innovation John R. Evans Leaders fund (#148035) awarded to JAM. RM was supported by an FPU predoctoral fellows from the Spanish Ministry of Education and Science (ref. FPU15/03332; EST18/00001).es_ES
dc.subjectEstrogenic chemicalses_ES
dc.subjectMetabolic disruptiones_ES
dc.titleAcute and long-term metabolic consequences of early developmental Bisphenol A exposure in zebrafish (Danio rerio)es_ES
dc.description.peerreviewedPeer reviewedes_ES
oprm.item.hasRevisionno ko 0 false*
dc.contributor.orcidNavarro-Martín, Laia [0000-0001-6554-8833]es_ES
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