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Conserved function of zebrafish (Danio rerio) Gdf15 as a sepsis tolerance mediator

AuthorsPereiro, Patricia ; Librán-Pérez, Marta; Figueras Huerta, Antonio ; Novoa, Beatriz
Issue Date2020
CitationDevelopmental and Comparative Immunology 109: 103698 (2020)
AbstractGDF15 is frequently detected in patients suffering from various diseases, especially those associated with pro-inflammatory processes and/or metabolic disorders. Accordingly, sepsis, whose major complications are related to metabolic alterations and systemic inflammation, significantly increases the secretion of GDF15. Indeed, this cytokine could be considered a marker of sepsis severity. However, until the last several years, the involvement of GDF15 in these disorders had not been widely characterized. In mice, GDF15 was recently described as a pivotal inducer of sepsis tolerance by mediating metabolic alterations that reduce tissue damage. In this work we describe a zebrafish gdf15 gene. We found that gdf15 follows an expression pattern similar to that observed in mammals, being highly expressed in the liver and kidney and induced after pro-inflammatory stimuli. Moreover, larvae overexpressing gdf15 were more resistant to bacterial and viral challenges without affecting the pathogen load. Consequently, Gdf15 also protected zebrafish larvae against LPS-induced mortality. As in mice, zebrafish Gdf15 seems to induce sepsis tolerance by altering the metabolic parameters of the individuals
Description14 pages, 9 figures, 1 table
Publisher version (URL)https://doi.org/10.1016/j.dci.2020.103698
Appears in Collections:(IIM) Artículos
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