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| Título: | Dose-dependent improvement of cardiac function in a swine model of acute myocardial infarction after intracoronary administration of allogeneic heart-derived cells |
Autor: | Crisostomo, Veronica; Baez, Claudia; Abad, José Luis CSIC ORCID ; Sánchez, Belén; Álvarez, Virginia; Rosado, Rosalba; Gómez Mauricio, Guadalupe; Gheysens, Olivier; Blanco Blazquez, Virginia; Blázquez, Rebeca; Torán, José Luis; Casado, Javier G.; Aguilar, Susana; Janssens, Stefan; Sánchez-Margallo, Francisco M.; Rodríguez Borlado, Luis; Bernad, Antonio CSIC ORCID; Palacios, Itziar CSIC | Palabras clave: | Cardiac progenitor/stem cells CPC Acute myocardial infarction Swine model Allogeneic Intracoronary administration Intracoronary administration |
Fecha de publicación: | may-2019 | Editor: | BioMed Central | Citación: | Stem cell research and therapy 10: 152 (2019) | Resumen: | Allogeneic cardiac-derived progenitor cells (CPC) without immunosuppression could provide an effective ancillary therapy to improve cardiac function in reperfused myocardial infarction. We set out to perform a comprehensive preclinical feasibility and safety evaluation of porcine CPC (pCPC) in the infarcted porcine model, analyzing biodistribution and mid-term efficacy, as well as safety in healthy non-infarcted swine. | Versión del editor: | https://doi.org/10.1186/s13287-019-1237-6 | URI: | http://hdl.handle.net/10261/211108 | DOI: | 10.1186/s13287-019-1237-6 | E-ISSN: | 1757-6512 |
| Aparece en las colecciones: | (CNB) Artículos |
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| BERNAD, Antonio.pdf | Artículo pincipal | 7,61 MB | Adobe PDF |  Visualizar/Abrir |
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