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New experimental murine models for colorectal cancer

AuthorsLópez-Briones, T.; Ortega-Rodríguez, J., Cámara, Ana Belén; Fernández-Barral, A. ; Bustamante-Madrid, Pilar; Costales-Carrera, Alba; Zarich, Natasha; Oliva, José Luis; Barbáchano, Antonio ; Muñoz Terol, Alberto ; Anta, B.; Rojas-Cabañeros, José M.; Lucas de, M. P.
Issue Date15-Oct-2019
CitationXVIII Congreso de la Sociedad Española de Biología Celular (SEBC) (2019)
AbstractColorectal cancer (CRC) has the highest incidence rate in the Spanish population, and the third one worldwide. The most important challenge consists on the discovery of efficient disease treatments, due to high mortality rates in highly developed stages. Although the genetic mutations that lead to CRC are well established, directed therapies are not fully successful. For this reason, some researchers are seeking for new therapeutic targets that can address alternative approaches. In this way, our group has developed several animal models that can recapitulate CRC and offer different approaches to validate potential new targets. Our conditional inducible genetic murine models allow to study this disease at several stages (like tumor initiation or malignancy progression) and, more importantly, to evaluate the therapeutic potential of new strategies/therapies and targets on them. On the other hand, development of specific protocols with these experimental models also enable to study mutational changes and pathway deregulations associated with CRC, in order to better understand the biology of the disease. In this session we will highlight innovative proceedings that can be used with animal models to further combat CRC.
DescriptionTrabajo presentado en el XVIII Congreso de la Sociedad Española de Biología Celular (SEBC), celebrado en Badajoz (España) del 15 al 18 de octubre de 2019.
Appears in Collections:(IIBM) Comunicaciones congresos
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