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dc.contributor.authorMurillo-Cuesta, Silvia-
dc.contributor.authorContreras, Julio-
dc.contributor.authorZurita, Esther-
dc.contributor.authorCediel, Rafael-
dc.contributor.authorCantero, Marta-
dc.contributor.authorVarela-Nieto, Isabel-
dc.contributor.authorMontoliu, Lluís-
dc.date.accessioned2010-02-04T12:50:05Z-
dc.date.available2010-02-04T12:50:05Z-
dc.date.issued2010-02-
dc.identifier.citationPigment Cell and Melanoma Research 23(1): 72-83 (2010)en_US
dc.identifier.issn1755-1471-
dc.identifier.urihttp://hdl.handle.net/10261/20698-
dc.description.abstractStrial melanocytes are required for normal development and correct functioning of the cochlea. Hearing deficits have been reported in albino individuals from different species, although melanin appears to be not essential for normal auditory function. We have analyzed the auditory brainstem responses (ABR) of two transgenic mice: YRT2, carrying the entire mouse tyrosinase (Tyr) gene expression-domain and undistinguishable from wild-type pigmented animals; and TyrTH, non-pigmented but ectopically expressing tyrosine hydroxylase (Th) in melanocytes, which generate the precursor metabolite, L-DOPA, but not melanin. We show that young albino mice present a higher prevalence of profound sensorineural deafness and a poorer recovery of auditory thresholds after noise-exposure than transgenic mice. Hearing loss was associated with absence of cochlear melanin or its precursor metabolites and latencies of the central auditory pathway were unaltered. In summary, albino mice show impaired hearing responses during ageing and after noise damage when compared to YRT2 and TyrTH transgenic mice, which do not show the albino-associated ABR alterations. These results demonstrate that melanin precursors, such as L-DOPA, have a protective role in the mammalian cochlea in age-related and noise-induced hearing lossen_US
dc.description.sponsorshipThis work was supported by funds from: the Spanish Ministry of Education and Science (BFU2006-12185) and the ‘Comunidad de Madrid’ (GR/SAL/0654/2004) to LM; the ‘Comunidad de Madrid’ (IV PRICYT IC0530), DIGNA Biotech (Ref. 065510), MICINN (SAF2008–00470) and the ‘Fundación Investigación Médica Mutua Madrileña’ (Ref. 20070504) to IVN; and the CIBERER (INTRA/08/761,1) to IVN and LM.-
dc.format.extent1018065 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoengen_US
dc.publisherWiley-Blackwellen_US
dc.rightsclosedAccessen_US
dc.subjectMelanocytesen_US
dc.subjectStria vascularisen_US
dc.subjectTyrosinaseen_US
dc.subjectTyrosine hydroxilaseen_US
dc.subjectTransgenic miceen_US
dc.subjectL-DOPAen_US
dc.subjectAlbinismen_US
dc.titleMelanin precursors prevent premature age-related and noise-induced hearing loss in albino miceen_US
dc.typeartículoen_US
dc.identifier.doi10.1111/j.1755-148X.2009.00646.x-
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://dx.doi.org/10.1111/j.1755-148X.2009.00646.xen_US
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