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Título: | Neuroprotective Effect of Hydroxytyrosol in Experimental Diabetes Mellitus |
Autor: | Reyes, J.J.; Villanueva, Beatriz; López-Villodres, J.A.; Cruz, José Pedro de la; Romero, L.; Rodríguez-Pérez, María Dolores; Rodríguez-Gutiérrez, Guillermo CSIC ORCID ; Fernández-Bolaños Guzmán, Juan CSIC ORCID ; González-Correa, José Antonio | Palabras clave: | Diabetes mellitus Hydroxytyrosol Inflammatory mediators Neuroprotection Oxidative stress |
Fecha de publicación: | 2017 | Editor: | American Chemical Society | Citación: | Journal of agricultural and food chemistry 65: 4378- 4383 (2017) | Resumen: | The aim of the study was to analyze the possible neuroprotective effect of hydroxytyrosol (HT) in diabetic animals in a model of hypoxia-reoxygenation. Rats (10 animals/group) were distributed in five groups: nondiabetic rats, control diabetic rats (DR), and DR rats treated for 2 months with 1, 5, or 10 mg/kg/day po HT. At the end of follow-up, an experimental model of hypoxia-reoxygenation in brain slices was tested. The DR group showed increased cell death, oxidative and nitrosative stress, and an increase in brain inflammatory mediators. These alterations were significantly greater in DR than in normoglycemic animals. HT significantly reduced oxidative (38.5-52.4% lipid peroxidation) and nitrosative stress (48.0-51.0% nitric oxide and 43.9-75.2% peroxynitrite concentration) and brain inflammatory mediators (18.6-40.6% prostaglandin E and 17.0-65.0% interleukin 1β concentration). Cell death was reduced by 25.9, 37.5, and 41.0% after the administration of 1, 5, or 10 mg/kg/day. The administration of HT in rats with experimental diabetes thus had a neuroprotective effect. | Versión del editor: | http://dx.doi.org/10.1021/acs.jafc.6b02945 | URI: | http://hdl.handle.net/10261/206633 | DOI: | 10.1021/acs.jafc.6b02945 | Identificadores: | doi: 10.1021/acs.jafc.6b02945 issn: 1520-5118 |
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