English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/206150
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Notch signaling in astrocytes mediates their morphological response to an inflammatory challenge

AuthorsAcaz-Fonseca, E.; Ortiz-Rodriguez, A.; Azcoitia, Íñigo; García-Segura, Luis M. ; Arévalo, María Ángeles
Issue Date2019
PublisherSpringer Nature
CitationCell Death Discovery 5 (2019)
AbstractIn the nervous system, Notch pathway has a prominent role in the control of neuronal morphology and in the determination of the astrocyte fate. However, the role of Notch in morphological astrocyte plasticity is unknown. Here, we have explored the role of Notch activity on the morphological reactivity of primary astrocytes in response to LPS, an inflammatory stimulus. We found that LPS induces reactive astrocyte morphology by the inhibition of Notch signaling via NFκB activation and Jagged upregulation. In contrast, IGF-1, an anti-inflammatory molecule, inhibits LPS-induced reactive astrocyte morphological phenotype by enhancing Notch signaling through the inhibition of NFκB and the activation of MAPK. Therefore, Notch signaling pathway emerges as a mediator of the regulation of astrocyte morphology by inflammatory and anti-inflammatory stimuli.
Publisher version (URL)http://dx.doi.org/10.1038/s41420-019-0166-6
URIhttp://hdl.handle.net/10261/206150
Identifiersdoi: 10.1038/s41420-019-0166-6
issn: 2058-7716
Appears in Collections:(IC) Artículos
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.