Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/205955
COMPARTIR / EXPORTAR:
SHARE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Controlling the balance between chromosome break repair pathways |
Autor: | Jimeno, Sonia CSIC; Mejías-Navarro, Fernando CSIC ORCID; Prados-Carvajal, Rosario CSIC; Huertas Sánchez, Pablo CSIC ORCID | Fecha de publicación: | 2019 | Editor: | Elsevier BV | Citación: | Advances in Protein Chemistry and Structural Biology 4: 95-134 (2019) | Resumen: | Broken chromosomes are among the most complex and more difficult to repair DNA lesions. The loss of the continuity of the DNA molecule presents a challenge to the cells, thus the repair of DNA double strand breaks might lead to genomic alterations. Indeed, to minimize this threat to genomic integrity, different DNA repair pathways can act on a broken chromosome. The balance between them is tightly controlled, and it heavily depends on global and local cellular cues. In this chapter, we review our current understanding on the repair of DNA double strand breaks and focus in the regulation of the balance between alternative pathways. Most of this modulation takes place at the level of DNA end resection. Here, we focus mostly on the local signals that control the repair pathway choice, as the global cues have been extensively reviewed recently. We described epigenetic marks that either facilitate or inhibit DNA resection and homologous recombination, from histone marks and chromatin remodelers to non-coding RNA and RNA-related factors. | Versión del editor: | https://doi.org/10.1016/bs.apcsb.2018.10.004 | URI: | http://hdl.handle.net/10261/205955 | DOI: | 10.1016/bs.apcsb.2018.10.004 | Identificadores: | doi: 10.1016/bs.apcsb.2018.10.004 isbn: 978-0-12-815559-2 issn: 1876-1623 |
Aparece en las colecciones: | (CABIMER) Libros y partes de libros |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
Page view(s)
146
checked on 21-abr-2024
Download(s)
26
checked on 21-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.