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Título: | Dietary carotenoid roles in redox homeostasis and human health |
Autor: | Barros, Marcelo P.; Rodrigo, María Jesús CSIC ORCID; Zacarías, Lorenzo CSIC ORCID | Palabras clave: | Oxidative stress Antioxidants Nrf2 Free radicals Apocarotenoids Inflammation Apoptosis Redox switch |
Fecha de publicación: | 22-may-2018 | Editor: | ACS Publications | Citación: | Journal of Agricultural and Food Chemistry 66 (23):5733-5740 (2020) | Resumen: | Classic nutrition believed that healthy diets should simply provide sufficient antioxidant loads to organisms, to hamper free radical processes and avoid oxidative stress. Current redox biology was proven much more intricate. Carotenoids are bioactive compounds in the human diet with a multifaceted role in redox metabolism. This perspective discusses the participation of α/β-carotene, lutein, zeaxanthin, lycopene, β-cryptoxanthin, astaxanthin, and derivatives in redox homeostasis focusing on (i) their antioxidant/pro-oxidant activities, (ii) control of gene expression via Nrf2–Keap1 and NF-κB pathways, and (iii) their link with (sub)cellular redox circuits, as part of the “redox code” that orchestrates physiological processes and health in humans. | Descripción: | This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Journal of Agricultural and Food Chemistry, copyright © American Chemical Society after peer review. To access the final edited and published work see https://doi.org/10.1021/acs.jafc.8b00866. | Versión del editor: | https://doi.org/10.1021/acs.jafc.8b00866 | URI: | http://hdl.handle.net/10261/205879 | DOI: | 10.1021/acs.jafc.8b00866 | ISSN: | 0021-8561 |
Aparece en las colecciones: | (IATA) Artículos |
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Barros-JAFC2018.pdf | Artículo principal | 559,82 kB | Adobe PDF | Visualizar/Abrir |
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