Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/205762
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis |
Autor: | Gallego-García, A.; Monera-Girona, Antonio J.; Pajares-Martínez, E.; Bastida-Martínez, Eva; Pérez-Castaño, Ricardo; Iniesta, A. A.; Fontes, Marta; Padmanabhan, Subramanian CSIC ORCID; Elías-Arnanz, Montserrat CSIC ORCID | Fecha de publicación: | 4-oct-2019 | Editor: | American Association for the Advancement of Science | Citación: | Science 366: 128-132 (2019) | Resumen: | Plasmalogens are glycerophospholipids with a hallmark sn-1 vinyl ether bond. These lipids are found in animals and some bacteria and have proposed membrane organization, signaling, and antioxidant roles. We discovered the plasmanylethanolamine desaturase activity that is essential for vinyl ether bond formation in a bacterial enzyme, CarF, which is a homolog of the human enzyme TMEM189. CarF mediates light-induced carotenogenesis in Myxococcus xanthus, and plasmalogens participate in sensing photooxidative stress through singlet oxygen. TMEM189 and other animal homologs could functionally replace CarF in M. xanthus, and knockout of TMEM189 in a human cell line eliminated plasmalogens. Discovery of the human plasmanylethanolamine desaturase will spur further study of plasmalogen biogenesis, functions, and roles in disease. | Descripción: | 4 pags., 4 figs. | Versión del editor: | http://dx.doi.org/10.1126/science.aay1436 | URI: | http://hdl.handle.net/10261/205762 | DOI: | 10.1126/science.aay1436 | Identificadores: | doi: 10.1126/science.aay1436 issn: 1095-9203 |
Aparece en las colecciones: | (IQF) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
75
checked on 24-mar-2024
WEB OF SCIENCETM
Citations
72
checked on 29-feb-2024
Page view(s)
195
checked on 28-mar-2024
Download(s)
24
checked on 28-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.