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Título

A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis

AutorGallego-García, A.; Monera-Girona, Antonio J.; Pajares-Martínez, E.; Bastida-Martínez, Eva; Pérez-Castaño, Ricardo; Iniesta, A. A.; Fontes, Marta; Padmanabhan, Subramanian CSIC ORCID; Elías-Arnanz, Montserrat CSIC ORCID
Fecha de publicación4-oct-2019
EditorAmerican Association for the Advancement of Science
CitaciónScience 366: 128-132 (2019)
ResumenPlasmalogens are glycerophospholipids with a hallmark sn-1 vinyl ether bond. These lipids are found in animals and some bacteria and have proposed membrane organization, signaling, and antioxidant roles. We discovered the plasmanylethanolamine desaturase activity that is essential for vinyl ether bond formation in a bacterial enzyme, CarF, which is a homolog of the human enzyme TMEM189. CarF mediates light-induced carotenogenesis in Myxococcus xanthus, and plasmalogens participate in sensing photooxidative stress through singlet oxygen. TMEM189 and other animal homologs could functionally replace CarF in M. xanthus, and knockout of TMEM189 in a human cell line eliminated plasmalogens. Discovery of the human plasmanylethanolamine desaturase will spur further study of plasmalogen biogenesis, functions, and roles in disease.
Descripción4 pags., 4 figs.
Versión del editorhttp://dx.doi.org/10.1126/science.aay1436
URIhttp://hdl.handle.net/10261/205762
DOI10.1126/science.aay1436
Identificadoresdoi: 10.1126/science.aay1436
issn: 1095-9203
Aparece en las colecciones: (IQF) Artículos




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