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Title

Severe acute respiratory syndrome coronavirus accessory proteins 6 and 9b interact in vivo

AuthorsCalvo Alcocer, Enrique ; DeDiego, Marta L. ; García, Pilar; López, Juan A.; Pérez-Breña, Pilar; Falcón, Ana
KeywordsSARS coronavirus
Protein 6
Protein 9b
Protein–protein interactions
LC–MS
Issue DateOct-2012
PublisherElsevier BV
CitationVirus Research 169(1): 282-288 (2012)
AbstractThe 3'proximal one-third of the severe acute respiratory syndrome coronavirus (SARS-CoV) genome encodes the structural proteins and eight accessory proteins, including 3a, 3b, 6, 7a, 7b, 8a, 8b and 9b, varying in length from 39 to 274. aa which do not share significant homology with viral proteins of known coronaviruses. The SARS-CoV protein 6 is 63 amino acids in length and has been previously involved in virus pathogenicity and replication. To further analyze this functions, the interaction of SARS-CoV protein 6 with other viral and/or cellular factors has been analyzed during SARS-CoV infective cycle. Protein 6 immunoprecipitation from extracts of SARS-CoV infected cells and mass spectrometry analysis revealed an interaction of viral proteins 6 and 9b in biologically relevant conditions. This interaction has been reinforced by co-localization of both proteins in the cytoplasm of SARS-CoV infected cells.
Publisher version (URL)http://dx.doi.org/10.1016/j.virusres.2012.07.012
URIhttp://hdl.handle.net/10261/204798
Identifiersdoi: 10.1016/j.virusres.2012.07.012
issn: 0168-1702
Appears in Collections:(VICYT) Colección Especial COVID-19
(CNB) Artículos
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