English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/203692
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Interplay between the Mediterranean diet and C-reactive protein genetic polymorphisms towards inflammation in adolescents

AuthorsArouca, Aline; Meirhaeghe, A.; Dallongeville, J.; Moreno, Luis A.; Lourenço, Gustavo Jacob; Marcos, Ascensión ; Huybrechts, Inge; Manios, Yannis; Lambrinou, Christina-Paulina; Gottrand, Frederic; Kafatos, Anthony; Kersting, Mathilde; Sjöström, Michael; Widhalm, Kurt; Ferrari, Marika; Molnar, Denes; González Gross, Marcela; Forsner, Maria; De Henauw, Stefaan; Michels, Nathalie
KeywordsC-reactive protein
Single nucleotide polymorphism
Mediterranean diet
Issue Date2019
CitationClinical Nutrition: (2019)
Abstract[Aim]: From a nutrigenetics perspective, we aim to investigate the moderating role of the Mediterranean diet and each of its subgroups in the association between C-reactive protein (CRP) gene polymorphisms and CRP blood concentration in adolescents. [Methods]: In 562 adolescents (13–17 y) of the European HELENA study, data was available on circulating CRP levels as inflammatory biomarker, three CRP gene SNPs (rs3093068, rs1204, rs1130864), food intake determined by a self-administered computerized 24 h-dietary recall for 2 days, and body composition. A 9-point Mediterranean diet score and each food subgroup were tested as moderator via SNP*diet interaction. Analyzes were adjusted for age, sex, puberty, adiposity and socioeconomic status. [Results]: The minor allele frequencies of rs3093068 and rs1130864 SNPs (GG and TT, respectively) were associated with higher CRP concentrations, while rs1205 (CT/TT) was associated with lower CRP concentrations. There were significant interactions between rs3093068 and Mediterranean diet (B = −0.1139, p = 0.011), or the fish food subgroup (B = −0.0090, p = 0.022), so that those with the highest genetic CRP risk underwent the highest CRP attenuation by a healthier diet. Although the effect of diet and SNP was substantial, the explained variance by interaction was only 1%. [Conclusion]: Greater adherence to the Mediterranean diet and particularly its fish component was associated with a lower CRP blood concentrations especially in those at highest genetic risk due to the rs3093068 SNP.
DescriptionIn Press.
Publisher version (URL)https://doi.org/10.1016/j.clnu.2019.08.016
Identifiersdoi: 10.1016/j.clnu.2019.08.016
e-issn: 1532-1983
issn: 0261-5614
Appears in Collections:(ICTAN) Artículos
Files in This Item:
File Description SizeFormat 
interplayadolescent.pdf655,48 kBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.