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Meta-analysis of the rs243865 MMP-2 polymorphism and age-related macular degeneration risk

AuthorsUsategui-Martín, Ricardo; Pastor-Idoate, Salvador; Chamorro, Antonio J.; Fernández, Itziar; Fernández-Bueno, Iván; Marcos-Martín, Miguel; González-Sarmiento, Rogelio ; Pastor, Jose Carlos
Issue Date7-Mar-2019
PublisherPublic Library of Science
CitationPLoS ONE 14(2): e0213624 (2019)
Abstract[Purpose]: Several researchers have suggested that the rs243865 (16q13-q21) polymorphism in the promoter region of the metalloproteinase-2 (MMP-2) gene could be associated with an increased risk of developing age-related macular degeneration (AMD). However, previous results remain inconclusive. To clarify this controversy, we conducted a meta-analysis of the relationship between rs243865 of MMP-2 and AMD. [Methods]: We included 6 independent case-control studies involving 1,682 AMD patients and 2,295 healthy subjects. The association between the rs243865 polymorphism and AMD was examined by the overall odds ratio (OR) with a 95% confidence interval (CI). We used a recessive genetic model analysis, sensitivity analysis, and assessment of bias in our meta-analysis. [Results]: Our results showed that there was no significant association between the variant T allele (p-value = 0.10, OR [95%CI] = 0.95 [0.82–1.10]) or the CT+TT genotype (p-value = 0.16, OR [95%CI] = 0.92 [0.76–1.12]) of rs243865 MMP-2 polymorphism and the presence of AMD. [Conclusions]: The rs243865 MMP-2 polymorphism was not associated with an increased risk of developing AMD. The MMP-2 (-1306 C>T) promoter variant is unlikely to have a major role in AMD risk susceptibility.
Description© 2019 Usategui-Martín et al.
Publisher version (URL)http://dx.doi.org/10.1371/journal.pone.0213624
Appears in Collections:(IBMCC) Artículos
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