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Título

Immunoglobulin gene rearrangement IGHV3-48 is a predictive marker of histological transformation into aggressive lymphoma in follicular lymphomas

AutorGarcía-Alvarez, María; Alonso-Álvarez, Sara; Prieto-Conde, Isabel; Jiménez, Cristina; Sarasquete, María Eugenia; Chillón, M. del Carmen; Medina, Alejandro; Balanzategui, Ana; Maldonado, Rebeca; Antón, Alicia; Puig, Noemi; Rodríguez, Marta; Blanco, Óscar; Tamayo, Pilar; González-Calle, Verónica; Martín, Alejandro; García-Sanz, Ramón; González, Marcos CSIC ORCID ; Caballero, Maria Dolores; Alcoceba, Miguel
Palabras claveB-cell lymphoma
Risk factors
Fecha de publicación2019
EditorSpringer Nature
CitaciónBlood Cancer Journal 9: 52 (2019)
ResumenFollicular lymphoma (FL) is a heterogeneous disease whose pathogenesis remains partially unknown. Around 20% of FL patients experience early progression or treatment-refractory disease and 2–3% of patients per year experience histological transformation (HT) into a more aggressive lymphoma (tFL). Here, we evaluate the immunoglobulin heavy chain variable (IGHV) gene usage and mutational status in 187 FL cases to assess its impact on clinical outcome and histological transformation. The IGHV gene repertoire was remarkably biased in FL. The IGHV4-34 (14%), IGHV3-23 (14%), IGHV3-48 (10%), IGHV3-30 (9%) and IGHV3-21 (7%) genes accounted for more than half of the whole cohort. IGHV3-48 was overrepresented in cases of tFL (19%) compared with non-transformed FL at 5 years (5%, P = 0.05). Patients with the IGHV3-48 gene were significantly more likely to have had HT after 10 years than those who used other genes (71% vs. 25%, P < 0.05), irrespective of the therapy they received. Moreover, IGHV3-30 was also overrepresented in cases of FL (9%) and tFL (13%) compared with diffuse large B-cell lymphoma in which it was nearly absent. In conclusion, our results indicate a role for antigen selection in the development of FL, while the use of IGHV3-48 could help predict histological transformation.
Descripción© The Author(s) 2019.
Versión del editorhttp://dx.doi.org/10.1038/s41408-019-0213-9
URIhttp://hdl.handle.net/10261/203394
DOI10.1038/s41408-019-0213-9
ISSN2044-5385
E-ISSN2044-5385
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