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Title

Eco-friendly synthesis of Te nanostructures with antibacterial and anticancer properties

AuthorsMedina Cruz, David; Vernet Crua, Ada; González Sagardoy, María Ujué ; Martínez-Orellana, Lidia ; Tien-Street, William; Zhang, Bohan; Huang, Xinjing; Nieto-Argüello, Alfonso; Cholula-Díaz, Jorge L.; Huttel, Yves ; García-Martín, José Miguel ; Webster, Thomas J.
Issue Date6-Jun-2019
Citation2nd Spanish Conference on Biomedical Applications of Nanomaterials (2019)
AbstractBacterial infections and cancer are two of the most significant issues that the current healthcare system should tackle nowadays. Traditional routes for the synthesis of the different compounds, drugs and nanostructures that are developed as potential solutions for those problems usually have several limitations, such as the use of harsh chemicals and production of toxic by-products with limited biocompatibility. In that sense, green chemistry offers a suitable approach, with safe and environmentally friendly manufacturing and minimal use of toxic chemicals. In this work, effective green routes for the synthesis of Te nanostructures are presented, based on hydrothermal or microwave-assisted reactions employing either starch [1], either citric juice (from orange, lemon or lime) [2] as unique reducing and stabilizing agents. The nanostructures were extensively characterized in terms of morphology, surface chemistry and composition, by means of transmission electron microscopy (TEM), scanning electron microscopy (SEM) with energy-dispersive X-ray analysis (EDX), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). Depending on the fabrication parameters, long nanowires, nanorods or cubic shaped nanoparticles were obtained. These Te nanostructures showed antibacterial activity against both Gram-negative and -positive bacteria in a range of concentrations from 5 to 50 μg mL−1. Cytotoxicity studies were accomplished, showing a dose-dependent anticancer effect towards human melanoma cells for concentrations up to 100 μg mL−1, remaining cytocompatible towards human healthy fibroblast cells at concentrations below 50 μg mL−1 for the majority of Te morphologies. These antibacterial and anticancer properties were correlated with the production of reactive oxygen species (ROS). This study suggests that green chemistry approaches for producing Te nanostructures may not only reduce adverse environmental effects resulting from traditional synthetic chemistry methods, but can be effective in interesting health care applications.
DescriptionTrabajo presentado en el 2nd Spanish Conference on Biomedical Applications of Nanomaterials (SBAN), celebrado en Madrid (España) los días 6 y 7 de junio de 2019
URIhttp://hdl.handle.net/10261/203240
Appears in Collections:(ICMM) Comunicaciones congresos
(IMN-CNM) Comunicaciones congresos
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