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Título: | A gene regulatory network to control EMT programs in development and disease |
Autor: | Fazilaty, Hassan CSIC ORCID; Rago, Luciano CSIC ORCID; Kass Youssef, Khalil CSIC ORCID; Ocaña, Oscar H. CSIC ORCID; Garcia-Asencio, Francisco CSIC ORCID; Arcas, Aída CSIC ORCID; Galcerán, Joan CSIC ORCID; Nieto, M. Ángela CSIC ORCID | Fecha de publicación: | 2019 | Editor: | Springer Nature | Citación: | Nature Communications 10: 5115 (2019) | Resumen: | The Epithelial to Mesenchymal Transition (EMT) regulates cell plasticity during embryonic development and in disease. It is dynamically orchestrated by transcription factors (EMT-TFs), including Snail, Zeb, Twist and Prrx, all activated by TGF-β among other signals. Here we find that Snail1 and Prrx1, which respectively associate with gain or loss of stem-like properties and with bad or good prognosis in cancer patients, are expressed in complementary patterns during vertebrate development and in cancer. We show that this complementarity is established through a feedback loop in which Snail1 directly represses Prrx1, and Prrx1, through direct activation of the miR-15 family, attenuates the expression of Snail1. We also describe how this gene regulatory network can establish a hierarchical temporal expression of Snail1 and Prrx1 during EMT and validate its existence in vitro and in vivo, providing a mechanism to switch and select different EMT programs with important implications in development and disease. | Versión del editor: | http://dx.doi.org/10.1038/s41467-019-13091-8 | URI: | http://hdl.handle.net/10261/203222 | DOI: | 10.1038/s41467-019-13091-8 | Identificadores: | doi: 10.1038/s41467-019-13091-8 issn: 2041-1723 |
Aparece en las colecciones: | (IC) Artículos (IN) Artículos |
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a gene regulatory network to control EMT.pdf | 2,98 MB | Adobe PDF | Visualizar/Abrir |
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