English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/202949
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Cimp-Positive Status is More Representative in Multiple Colorectal Cancers than in Unique Primary Colorectal Cancers

AuthorsTapial, Sandra; Olmedillas-López, Susana; Rueda, Daniel; Arriba, María; García, Juan L. ; Vivas, Alfredo; Pérez García, Jessica; Pena-Couso, Laura; Olivera, Rocío; Rodríguez, Yolanda; García-Arranz, Mariano; García-Olmo, Damián; González-Sarmiento, Rogelio ; Urioste, Miguel; Goel, Ajay; Perea, José
KeywordsCancer genomics
Colorectal cancer
Issue Date2019
PublisherSpringer Nature
CitationScientific Reports 9: 10516 (2019)
AbstractColorectal cancer (CRC) with CpG island methylator phenotype (CIMP) is recognized as a subgroup of CRC that shows association with particular genetic defects and patient outcomes. We analyzed CIMP status of 229 individuals with CRC using an eight-marker panel (CACNA1G, CDKN2A, CRABP1, IGF2, MLH1, NEUROG1, RUNX3 and SOCS1); CIMP-(+) tumors were defined as having ≥ 5 methylated markers. Patients were divided into individuals who developed a “unique” CRC, which were subclassified into early-onset CRC (EOCRC) and late-onset CRC (LOCRC), and patients with multiple primary CRCs subclassified into synchronous CRC (SCRC) and metachronous CRC (MCRC). We found 9 (15.2%) CIMP-(+) EOCRC patients related with the proximal colon (p = 0.008), and 19 (26.8%) CIMP-(+) LOCRC patients associated with tumor differentiation (p = 0.045), MSI status (p = 0.021) and BRAF mutation (p = 0.001). Thirty-five (64.8%) SCRC patients had at least one CIMP-(+) tumor and 20 (44.4%) MCRC patients presented their first tumor as CIMP-(+). Thirty-nine (72.2%) SCRC patients showed concordant CIMP status in their simultaneous tumors. The differences in CIMP-(+) frequency between groups may reflect the importance of taking into account several criteria for the development of multiple primary neoplasms. Additionally, the concordance between synchronous tumors suggests CIMP status is generally maintained in SCRC patients.
Description© The Author(s) 2019.
Publisher version (URL)http://dx.doi.org/10.1038/s41598-019-47014-w
Appears in Collections:(IBMCC) Artículos
Files in This Item:
File Description SizeFormat 
Cimp_Positive_Tapial_Art2019.pdf3,2 MBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.