Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/202452
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | A key metabolic gene for recurrent freshwater colonization and radiation in fishes |
Autor: | Ishikawa, Asano; Kabeya, Naoki; Ikeya, Koki; Kakioka, Ryo; Cech, Jennifer N.; Osada, Naoki; Leal, Miguel C.; Inoue, Jun; Kume, Manabu; Toyoda, Atsushi; Tezuka, Ayumi; Nagano, Atsushi J.; Suzuki, Yuto; Kokita, Tomoyuki; Takahashi, Hiroshi; Lucek, Kay; Marques, David; Takehana, Yusuke; Naruse, Kiyoshi; Mori, Seiichi; Ladd, Nemiah; Schubert, Carsten J.; Matthews, Blake; Peichel, Catherine L.; Seehausen, Ole; Yoshizaki, Goro; Kitano, Jun; Yamasaki,Yo Y. | Fecha de publicación: | 31-may-2019 | Editor: | American Association for the Advancement of Science | Citación: | Science 364(6443): 886-889 (2019) | Resumen: | Colonization of new ecological niches has triggered large adaptive radiations. Although some lineages have made use of such opportunities, not all do so. The factors causing this variation among lineages are largely unknown. Here, we show that deficiency in docosahexaenoic acid (DHA), an essential w-3 fatty acid, can constrain freshwater colonization by marine fishes. Our genomic analyses revealed multiple independent duplications of the fatty acid desaturase gene Fads2 in stickleback lineages that subsequently colonized and radiated in freshwater habitats, but not in close relatives that failed to colonize. Transgenic manipulation of Fads2 in marine stickleback increased their ability to synthesize DHA and survive on DHA-deficient diets. Multiple freshwater ray-finned fishes also show a convergent increase in Fads2 copies, indicating its key role in freshwater colonization. | Versión del editor: | http://dx.doi.org/10.1126/science.aau5656 | URI: | http://hdl.handle.net/10261/202452 | DOI: | 10.1126/science.aau5656 | Identificadores: | doi: 10.1126/science.aau5656 e-issn: 1095-9203 issn: 0036-8075 |
Referencias: | Ishikawa, Asano; Kabeya, Naoki; Ikeya, Koki; Kakioka, Ryo; Cech, Jennifer N.; Osada, Naoki; Leal, Miguel C.; Inoue, Jun; Kume, Manabu; Toyoda, Atsushi; Tezuka, Ayumi; Nagano, Atsushi J.: Yamasaki,Yo Y.; Suzuki, Yuto; Kokita, Tomoyuki; Takahashi, Hiroshi; Lucek, Kay; Marques, David; Takehana, Yusuke; Naruse, Kiyoshi; Mori, Seiichi; Monroig, Óscar; Ladd, Nemiah; Schubert, Carsten J.; Matthews, Blake; Peichel, Catherine L.; Seehausen, Ole; Yoshizaki, Goro; Kitano, Jun; 2019; Data from: A key metabolic gene for recurrent freshwater colonization and radiation in fishes [Dataset]; Dryad; Version 1; https://doi.org/10.5061/dryad.14rf353 |
Aparece en las colecciones: | (IATS) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Key_metabolic.pdf | 6,77 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
92
checked on 22-mar-2024
WEB OF SCIENCETM
Citations
85
checked on 25-feb-2024
Page view(s)
200
checked on 28-mar-2024
Download(s)
466
checked on 28-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.