Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/202452
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Título

A key metabolic gene for recurrent freshwater colonization and radiation in fishes

AutorIshikawa, Asano; Kabeya, Naoki; Ikeya, Koki; Kakioka, Ryo; Cech, Jennifer N.; Osada, Naoki; Leal, Miguel C.; Inoue, Jun; Kume, Manabu; Toyoda, Atsushi; Tezuka, Ayumi; Nagano, Atsushi J.; Suzuki, Yuto; Kokita, Tomoyuki; Takahashi, Hiroshi; Lucek, Kay; Marques, David; Takehana, Yusuke; Naruse, Kiyoshi; Mori, Seiichi; Ladd, Nemiah; Schubert, Carsten J.; Matthews, Blake; Peichel, Catherine L.; Seehausen, Ole; Yoshizaki, Goro; Kitano, Jun; Yamasaki,Yo Y.
Fecha de publicación31-may-2019
EditorAmerican Association for the Advancement of Science
CitaciónScience 364(6443): 886-889 (2019)
ResumenColonization of new ecological niches has triggered large adaptive radiations. Although some lineages have made use of such opportunities, not all do so. The factors causing this variation among lineages are largely unknown. Here, we show that deficiency in docosahexaenoic acid (DHA), an essential w-3 fatty acid, can constrain freshwater colonization by marine fishes. Our genomic analyses revealed multiple independent duplications of the fatty acid desaturase gene Fads2 in stickleback lineages that subsequently colonized and radiated in freshwater habitats, but not in close relatives that failed to colonize. Transgenic manipulation of Fads2 in marine stickleback increased their ability to synthesize DHA and survive on DHA-deficient diets. Multiple freshwater ray-finned fishes also show a convergent increase in Fads2 copies, indicating its key role in freshwater colonization.
Versión del editorhttp://dx.doi.org/10.1126/science.aau5656
URIhttp://hdl.handle.net/10261/202452
DOI10.1126/science.aau5656
Identificadoresdoi: 10.1126/science.aau5656
e-issn: 1095-9203
issn: 0036-8075
ReferenciasIshikawa, Asano; Kabeya, Naoki; Ikeya, Koki; Kakioka, Ryo; Cech, Jennifer N.; Osada, Naoki; Leal, Miguel C.; Inoue, Jun; Kume, Manabu; Toyoda, Atsushi; Tezuka, Ayumi; Nagano, Atsushi J.: Yamasaki,Yo Y.; Suzuki, Yuto; Kokita, Tomoyuki; Takahashi, Hiroshi; Lucek, Kay; Marques, David; Takehana, Yusuke; Naruse, Kiyoshi; Mori, Seiichi; Monroig, Óscar; Ladd, Nemiah; Schubert, Carsten J.; Matthews, Blake; Peichel, Catherine L.; Seehausen, Ole; Yoshizaki, Goro; Kitano, Jun; 2019; Data from: A key metabolic gene for recurrent freshwater colonization and radiation in fishes [Dataset]; Dryad; Version 1; https://doi.org/10.5061/dryad.14rf353
Aparece en las colecciones: (IATS) Artículos




Ficheros en este ítem:
Fichero Descripción Tamaño Formato
Key_metabolic.pdf6,77 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo

CORE Recommender

SCOPUSTM   
Citations

92
checked on 22-mar-2024

WEB OF SCIENCETM
Citations

85
checked on 25-feb-2024

Page view(s)

200
checked on 28-mar-2024

Download(s)

466
checked on 28-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.