Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/202400
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | The Crosstalk between Cardiac Lipotoxicity and Mitochondrial Oxidative Stress in the Cardiac Alterations in Diet-Induced Obesity in Rats |
Autor: | Jiménez-González, Sara; Marín-Royo, Gema; Jurado-López, Raquel; Bartolomé, María Visitacion; Romero-Miranda, Ana; Luaces, María; Islas, Fabián; Nieto, María Luisa CSIC ORCID; Martínez-Martínez, Ernesto; Cachofeiro, Victoria | Palabras clave: | Cardiac fibrosis Cardiac hypertrophy Cardiac lipotoxicity Mitochondrial function Obesity Oxidative stress |
Fecha de publicación: | 2020 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | Cells 9(2): 451 (2020) | Resumen: | The impact of the mitochondria-targeted antioxidant MitoQ was evaluated in the cardiac alterations associated with obesity. Male Wistar rats were fed either a high fat diet (HFD, 35% fat) or a standard diet (CT, 3.5% fat) for 7 weeks and treated with MitoQ (200 µM). The effect of MitoQ (5 nM) in rat cardiac myoblasts treated for 24 h with palmitic acid (PA, 200 µM) was evaluated. MitoQ reduced cardiac oxidative stress and prevented the development of cardiac fibrosis, hypertrophy, myocardial 18-FDG uptake reduction, and mitochondrial lipid remodeling in HFD rats. It also ameliorated cardiac mitochondrial protein level changes observed in HFD: reductions in fumarate hydratase, complex I and II, as well as increases in mitofusin 1 (MFN1), peroxisome proliferator-activated receptor gamma coactivator 1-alpha, and cyclophilin F (cycloF). In vitro, MitoQ prevented oxidative stress and ameliorated alterations in mitochondrial proteins observed in palmitic acid (PA)-stimulated cardiac myoblasts: increases in carnitine palmitoyltransferase 1A, cycloF, and cytochrome C. PA induced phosphorylation of extracellular signal-regulated kinases and nuclear factor-κB p65. Therefore, the data show the beneficial effects of MitoQ in the cardiac damage induced by obesity and suggests a crosstalk between lipotoxicity and mitochondrial oxidative stress in this damage. | Descripción: | © 2020 by the authors. | Versión del editor: | https://doi.org/10.3390/cells9020451 | URI: | http://hdl.handle.net/10261/202400 | DOI: | 10.3390/cells9020451 | E-ISSN: | 2073-4409 |
Aparece en las colecciones: | (IBGM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Crosstalk_Jimenez_Art2020.pdf | 3,26 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
17
checked on 22-abr-2024
SCOPUSTM
Citations
26
checked on 15-abr-2024
WEB OF SCIENCETM
Citations
24
checked on 29-feb-2024
Page view(s)
169
checked on 22-abr-2024
Download(s)
132
checked on 22-abr-2024