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http://hdl.handle.net/10261/202199
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Martín-Rodríguez, Juan Francisco | es_ES |
dc.contributor.author | Ramos‐Herrero, Víctor Darío | es_ES |
dc.contributor.author | Parras, Gloria G. | es_ES |
dc.contributor.author | Flores-Martínez, Alvaro | es_ES |
dc.contributor.author | Madrazo Atutxa, Ainara | es_ES |
dc.contributor.author | Cano González, David A. | es_ES |
dc.contributor.author | Gruart, Agnès | es_ES |
dc.contributor.author | Delgado‐García, José María | es_ES |
dc.contributor.author | Leal Cerro, Alfonso | es_ES |
dc.contributor.author | Leal‐Campanario, Rocío | es_ES |
dc.date.accessioned | 2020-02-27T14:14:23Z | - |
dc.date.available | 2020-02-27T14:14:23Z | - |
dc.date.issued | 2020-06 | - |
dc.identifier.citation | Acta Physiologica 229(2): e13293 (2020) | es_ES |
dc.identifier.issn | 1748-1708 | - |
dc.identifier.uri | http://hdl.handle.net/10261/202199 | - |
dc.description.abstract | [Aim] Besides their metabolic and endocrine functions, the growth hormone (GH) and its mediated factor, the insulin‐like growth factor I (IGF‐I), have been implicated in different brain functions, including neurogenesis. Long‐lasting elevated GH and IGF‐I levels result in non‐reversible somatic, endocrine and metabolic morbidities. However, the subcutaneous implantation of the GH‐secreting (GH‐S) GC cell line in rats leads to the controllable over‐secretion of GH and elevated IGF‐I levels, allowing the experimental study of their short‐term effects on brain functions. | es_ES |
dc.description.abstract | [Methods] Adult rats were implanted with GC cells and checked 10 weeks later, when a GH/IGF‐I‐secreting tumour was already formed. | es_ES |
dc.description.abstract | [Results] Tumour‐bearing rats acquired different operant conditioning tasks faster and better than controls and tumour‐resected groups. They also presented better retentions of long‐term memories in the passive avoidance test. Experimentally evoked long‐term potentiation (LTP) in the hippocampus was also larger and longer lasting in the tumour bearing than in the other groups. Chronic adult‐onset of GH/IGF‐I hypersecretion caused an acceleration of early progenitors, facilitating a faster neural differentiation, maturation and integration in the dentate gyrus, and increased the complexity of dendritic arbours and spine density of granule neurons. | es_ES |
dc.description.abstract | [Conclusion] Thus, adult‐onset hypersecretion of GH/IGF‐I improves neurocognitive functions, long‐term memories, experimental LTP and neural differentiation, migration and maturation. | es_ES |
dc.description.sponsorship | This study was supported by a grant from the Junta de Andalucía (PI‐0302‐2012) to RL‐C and by grants from the Spanish Ministry of Economy and Competitiveness (BFU2014‐56692‐R and BFU2017‐82375‐R) and the Junta de Andalucía (BIO122) to AG and JMD‐G, and grants from the ISCIII‐Subdirección General de Evaluación y Fomento de la Investigación co‐funded with Fondos FEDER (PI16/00175) and the Nicolás Monardes program of the Andalusian Ministry of Health (C‐0015‐2014) to DAC. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley-Blackwell | es_ES |
dc.relation | BFU2017-82375-R/AEI/10.13039/501100011033 | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2014‐56692‐R | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/BFU2017-82375-R | es_ES |
dc.relation | BFU2017-82375-R/AEI/10.13039/501100011033 | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | Behavioral tests | es_ES |
dc.subject | Growth hormone | es_ES |
dc.subject | Growth‐hormone‐secreting tumours | es_ES |
dc.subject | Insulin‐like growth factor type I | es_ES |
dc.subject | LTP | es_ES |
dc.subject | Neurogenesis | es_ES |
dc.title | Chronic adult‐onset of growth hormone/IGF‐I hypersecretion improves cognitive functions and LTP and promotes neuronal differentiation in adult rats | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1111/apha.13293 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1111/apha.13293 | es_ES |
dc.identifier.e-issn | 1748-1716 | - |
dc.contributor.funder | Junta de Andalucía | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación (España) | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación (España) | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011033 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011011 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
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