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dc.contributor.authorMartín-Rodríguez, Juan Franciscoes_ES
dc.contributor.authorRamos‐Herrero, Víctor Daríoes_ES
dc.contributor.authorParras, Gloria G.es_ES
dc.contributor.authorFlores-Martínez, Alvaroes_ES
dc.contributor.authorMadrazo Atutxa, Ainaraes_ES
dc.contributor.authorCano González, David A.es_ES
dc.contributor.authorGruart, Agnèses_ES
dc.contributor.authorDelgado‐García, José Maríaes_ES
dc.contributor.authorLeal Cerro, Alfonsoes_ES
dc.contributor.authorLeal‐Campanario, Rocíoes_ES
dc.date.accessioned2020-02-27T14:14:23Z-
dc.date.available2020-02-27T14:14:23Z-
dc.date.issued2020-06-
dc.identifier.citationActa Physiologica 229(2): e13293 (2020)es_ES
dc.identifier.issn1748-1708-
dc.identifier.urihttp://hdl.handle.net/10261/202199-
dc.description.abstract[Aim] Besides their metabolic and endocrine functions, the growth hormone (GH) and its mediated factor, the insulin‐like growth factor I (IGF‐I), have been implicated in different brain functions, including neurogenesis. Long‐lasting elevated GH and IGF‐I levels result in non‐reversible somatic, endocrine and metabolic morbidities. However, the subcutaneous implantation of the GH‐secreting (GH‐S) GC cell line in rats leads to the controllable over‐secretion of GH and elevated IGF‐I levels, allowing the experimental study of their short‐term effects on brain functions.es_ES
dc.description.abstract[Methods] Adult rats were implanted with GC cells and checked 10 weeks later, when a GH/IGF‐I‐secreting tumour was already formed.es_ES
dc.description.abstract[Results] Tumour‐bearing rats acquired different operant conditioning tasks faster and better than controls and tumour‐resected groups. They also presented better retentions of long‐term memories in the passive avoidance test. Experimentally evoked long‐term potentiation (LTP) in the hippocampus was also larger and longer lasting in the tumour bearing than in the other groups. Chronic adult‐onset of GH/IGF‐I hypersecretion caused an acceleration of early progenitors, facilitating a faster neural differentiation, maturation and integration in the dentate gyrus, and increased the complexity of dendritic arbours and spine density of granule neurons.es_ES
dc.description.abstract[Conclusion] Thus, adult‐onset hypersecretion of GH/IGF‐I improves neurocognitive functions, long‐term memories, experimental LTP and neural differentiation, migration and maturation.es_ES
dc.description.sponsorshipThis study was supported by a grant from the Junta de Andalucía (PI‐0302‐2012) to RL‐C and by grants from the Spanish Ministry of Economy and Competitiveness (BFU2014‐56692‐R and BFU2017‐82375‐R) and the Junta de Andalucía (BIO122) to AG and JMD‐G, and grants from the ISCIII‐Subdirección General de Evaluación y Fomento de la Investigación co‐funded with Fondos FEDER (PI16/00175) and the Nicolás Monardes program of the Andalusian Ministry of Health (C‐0015‐2014) to DAC.es_ES
dc.language.isoenges_ES
dc.publisherWiley-Blackwelles_ES
dc.relationBFU2017-82375-R/AEI/10.13039/501100011033-
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2014‐56692‐Res_ES
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/BFU2017-82375-Res_ES
dc.relationBFU2017-82375-R/AEI/10.13039/501100011033es_ES
dc.rightsclosedAccesses_ES
dc.subjectBehavioral testses_ES
dc.subjectGrowth hormonees_ES
dc.subjectGrowth‐hormone‐secreting tumourses_ES
dc.subjectInsulin‐like growth factor type Ies_ES
dc.subjectLTPes_ES
dc.subjectNeurogenesises_ES
dc.titleChronic adult‐onset of growth hormone/IGF‐I hypersecretion improves cognitive functions and LTP and promotes neuronal differentiation in adult ratses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1111/apha.13293-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1111/apha.13293es_ES
dc.identifier.e-issn1748-1716-
dc.contributor.funderJunta de Andalucíaes_ES
dc.contributor.funderAgencia Estatal de Investigación (España)-
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderAgencia Estatal de Investigación (España)es_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100011033es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100011011es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
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