Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/202127
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Bioavailability of coenzyme Q10 supplements depends on carrier lipids and solubilization |
Autor: | López-Lluch, Guillermo CSIC ORCID CVN ; Pozo-Cruz, Jesús del; Sánchez-Cuesta, Ana CSIC ORCID; Cortés-Rodríguez, Ana Belén CSIC ORCID; Navas, Plácido CSIC ORCID | Palabras clave: | Ubiquinol Ubiquinone Bioavailability Human Coenzyme Q10 |
Fecha de publicación: | ene-2019 | Editor: | Elsevier BV | Citación: | Nutrition 57: 133-140 (2019) | Resumen: | [Objectives]: Bioavailability of supplements with coenzyme Q10 (CoQ10) in humans seems to depend on the excipients of formulations and on physiological characteristics of the individuals. The aim of this study was to determine which factors presented in CoQ10 supplements affect the different response to CoQ10 in humans. [Methods]: We tested seven different supplement formulations containing 100 mg of CoQ10 in 14 young, healthy individuals. Bioavailability was measured as area under the curve of plasma CoQ10 levels over 48 h after ingestion of a single dose. Measurements were repeated in the same group of 14 volunteers in a double-blind crossover design with a minimum of 4 wk washout between intakes. [Results]: Bioavailability of the formulations showed large differences that were statistically significant. The two best absorbable formulations were soft-gel capsules containing ubiquinone (oxidized CoQ10) or ubiquinol (reduced CoQ10). The matrix used to dissolve CoQ10 and the proportion and addition of preservatives such as vitamin C affected the bioavailability of CoQ10. Although control measurements documented that all formulations contained 100 mg of either CoQ10 or ubiquinol, some of the participants showed high and others lower capacity to reach high increase of CoQ10 in blood, indicating the participation of individual unknown physiological factors. [Conclusion]: This study highlights the importance of individually adapted selection of best formulations to reach the highest bioavailability of CoQ10 in humans. |
Versión del editor: | http://dx.doi.org/10.1016/j.nut.2018.05.020 | URI: | http://hdl.handle.net/10261/202127 | DOI: | 10.1016/j.nut.2018.05.020 | ISSN: | 0899-9007 | E-ISSN: | 1873-1244 |
Aparece en las colecciones: | (CABD) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
97
checked on 24-abr-2024
WEB OF SCIENCETM
Citations
80
checked on 27-feb-2024
Page view(s)
227
checked on 21-abr-2024
Download(s)
32
checked on 21-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.