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Title

Sidekick Is a Key Component of Tricellular Adherens Junctions that Acts to Resolve Cell Rearrangements

AuthorsLetizia, Annalisa ; He, DanQing; Astigarraga, Sergio; Colombelli, Julien; Hatini, Victor; Llimargas, Marta ; Treisman, Jessica E.
KeywordsTricellular adherens junction
Sidekick
Tension
Epithelium
Cell rearrangements
Trachea
Retina
Afadin
Zonula occludens
ZO-1
Actin
Issue Date5-Aug-2019
PublisherElsevier BV
CitationDevelopmental Cell 50(3): 313-326.e5 (2019)
AbstractTricellular adherens junctions are points of high tension that are central to the rearrangement of epithelial cells. However, the molecular composition of these junctions is unknown, making it difficult to assess their role in morphogenesis. Here, we show that Sidekick, an immunoglobulin family cell adhesion protein, is highly enriched at tricellular adherens junctions in Drosophila. This localization is modulated by tension, and Sidekick is itself necessary to maintain normal levels of cell bond tension. Loss of Sidekick causes defects in cell and junctional rearrangements in actively remodeling epithelial tissues like the retina and tracheal system. The adaptor proteins Polychaetoid and Canoe are enriched at tricellular adherens junctions in a Sidekick-dependent manner; Sidekick functionally interacts with both proteins and directly binds to Polychaetoid. We suggest that Polychaetoid and Canoe link Sidekick to the actin cytoskeleton to enable tricellular adherens junctions to maintain or transmit cell bond tension during epithelial cell rearrangements.
Publisher version (URL)http://dx.doi.org/10.1016/j.devcel.2019.07.007
URIhttp://hdl.handle.net/10261/201741
DOI10.1016/j.devcel.2019.07.007
ISSN1534-5807
E-ISSN1878-1551
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