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Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections

AuthorsAbascal, Estefanía; Herranz, Marta; Acosta, Fermín; Agapito, Juan; Cabibbe, Andrea M.; Monteserin, Johana; Ruiz Serrano, María Jesús; Gijón, Paloma; Fernández-González, Francisco; Lozano, Nuria; Chiner-Oms, Álvaro ; Cáceres, Tatiana; Gómez Pintado, Pilar; Acín, Enrique; Valencia, Eddy; Muñoz, Patricia; Comas, Iñaki ; Cirillo, Daniela M.; Ritacco, Viviana; Gotuzzo, Eduardo; García de Viedma, Darío
Issue Date17-Feb-2020
PublisherNature Publishing Group
CitationScientific Reports 10(1):2704 (2020)
AbstractIt is relevant to evaluate MDR-tuberculosis in prisons and its impact on the global epidemiology of this disease. However, systematic molecular epidemiology programs in prisons are lacking. A health-screening program performed on arrival for inmates transferred from Peruvian prisons to Spain led to the diagnosis of five MDR-TB cases from one of the biggest prisons in Latin America. They grouped into two MIRU-VNTR-clusters (Callao-1 and Callao-2), suggesting a reservoir of two prevalent MDR strains. A high-rate of overexposure was deduced because one of the five cases was coinfected by a pansusceptible strain. Callao-1 strain was also identified in 2018 in a community case in Spain who had been in the same Peruvian prison in 2002-5. A strain-specific-PCR tailored from WGS data was implemented in Peru, allowing the confirmation that these strains were currently responsible for the majority of the MDR cases in that prison, including a new mixed infection.
Description8 páginas, 4 figuras, 1 tabla. Información suplementaria accesible en: https://doi.org/10.1038/s41598-020-59373-w
Publisher version (URL)http://dx.doi.org/10.1038/s41598-020-59373-w
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