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Title

Peripheral CD39-expressing T regulatory cells are increased and associated with relapsing-remitting multiple sclerosis in relapsing patients

AuthorsÁlvarez Sánchez, Nuria; Cruz-Chamorro, Iván; Díaz Sánchez, María; Lardone, Patricia Judith; Guerrero, Miguel; Carrillo-Vico, Antonio
Issue Date19-Feb-2019
PublisherSpringer Nature
CitationScientific Reports 9: 2302 (2019)
AbstractCD39, an ectonucleotidase that hydrolyses pro-inflammatory ATP, is a marker of highly active and suppressive T regulatory cells (Tregs). Although CD39 has a role in Treg suppression and might be important in the control of neuroinflammation in relapsing-remitting multiple sclerosis (RR-MS), to date, there are contradictory reports concerning the Tregs expression of CD39 in RR-MS patients. Thus, our objectives were to assess the activity and expression of CD39, especially in Tregs from peripheral blood mononuclear cells (PBMCs) of relapsing RR-MS patients compared with control subjects and to evaluate the association of CD39+ Tregs with disability and the odds of RR-MS. The activity and expression of CD39 and the CD39+ Treg frequency were measured in PBMCs from 55 relapsing RR-MS patients (19 untreated and 36 receiving immunomodulatory treatment) and 55 age- and sex-paired controls. Moreover, the association between CD39+ Tregs and RR-MS was assessed by multivariate logistic regression. CD39 activity and the frequency of CD39-expressing Tregs were elevated in relapsing RR-MS patients. Moreover, CD39+ Tregs were significantly correlated with the EDSS score and were independently associated with the odds of RR-MS. Our results highlight the relevance of CD39+ Treg subset in the clinical outcomes of RR-MS.
Publisher version (URL)https://doi.org/10.1038/s41598-019-38897-w
URIhttp://hdl.handle.net/10261/201313
DOI10.1038/s41598-019-38897-w
E-ISSN2045-2322
Appears in Collections:(IBIS) Artículos
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