Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/201206
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Design and Synthesis of New 6-Nitro and 6-Amino- 3,3a,4,5-Tetrahydro-2H-Benzo[g]indazole Derivatives: Antiproliferative and Antibacterial Activity |
Autor: | Cuartas, Viviana; Crespo, María del Pilar; Priego, Eva María CSIC ORCID; Persoons, Leentje; Daelemans, Dirk; Camarasa Rius, María José CSIC ORCID; Insuasty, Braulio; Peréz-Pérez, María-Jesús CSIC ORCID | Palabras clave: | Indazole 2-benzylidene-1-tetralone Antiproliferative activity Antibacterial activity |
Fecha de publicación: | 2019 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | Molecules 24 : 4236 (2019) | Resumen: | New substituted benzo[g]indazoles functionalized with a 6-nitro and 6-amino groups have been synthesized by the reaction of benzylidene tetralones with hydrazine in acetic acid. The resulting conformationally-constrained compounds were evaluated for their antiproliferative activity against selected cancer cell lines. The nitro-based indazoles 11a, 11b, 12a and 12b have shown IC50 values between 5–15 μM against the lung carcinoma cell line NCI-H460. Moreover, the nitro compounds were tested for antibacterial activity where compounds 12a and 13b have shown MIC values of 250 and 62.5 μg/mL against N. gonorrhoeae with no hemolytic activity in human red blood cells (RBC). | Versión del editor: | http://dx.doi.org/10.3390/molecules24234236 | URI: | http://hdl.handle.net/10261/201206 | DOI: | 10.3390/molecules24234236 | ISSN: | 1420-3049 | E-ISSN: | 1420-3049 |
Aparece en las colecciones: | (IQM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
molecules-pirazolinas_2019.pdf | 846,86 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
2
checked on 23-abr-2024
WEB OF SCIENCETM
Citations
4
checked on 29-feb-2024
Page view(s)
175
checked on 24-abr-2024
Download(s)
228
checked on 24-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.