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Role of A-type lamins in signaling, transcription and chromatin organization

AuthorsAndrés, Vicente; González, José María
KeywordsNuclear envelope
gene transcription
cell signaling
Issue Date28-Dec-2009
PublisherRockefeller University Press
CitationJournal of Cell Biology 187(7): 945-57 (2009)
AbstractA-type lamins (lamin-A and -C), encoded by the LMNA gene, are major protein constituents of the mammalian nuclear lamina, a complex structure that acts as a scaffold for protein complexes that regulate nuclear structure and functions. Interest in these proteins has increased in recent years with the discovery that LMNA mutations cause a variety of human diseases termed laminopathies, including progeroid syndromes and disorders that primarily affect striated muscle, adipose, bone and neuronal tissues. In this review we discuss recent research supporting the concept that lamin-A/C and associated nuclear envelope proteins regulate gene expression in health and disease through interplay with signal transduction pathways, transcription factors and chromatin-associated proteins.
Description13 pages, 4 figures. -- PMID: 20038676 [PubMed]
Publisher version (URL)http://dx.doi.org/10.1083/jcb.200904124
Appears in Collections:(IBV) Artículos
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