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Título: | Maraviroc contributes to the restoration of the homeostasis of regulatory T-cell subsets in antiretroviral-naive HIV-infected subjects |
Autor: | Pozo-Balado, Maria del Mar del CSIC; Rosado-Sánchez, Isaac CSIC ORCID; Méndez-Lagares, Gema; Rodríguez-Méndez, M. del Mar; Ruiz-Mateos, Ezequiel CSIC ORCID; Rafii-El-Idrissi Benhnia, Mohamed CSIC ORCID CVN; Muñoz-Fernández, María Ángeles CSIC ORCID; Leal, Manuel CSIC; Pacheco, Yolanda M. CSIC ORCID | Palabras clave: | Regulatory T-cells HIV Maraviroc CCR5 Naive-Treg Effector-Treg non-Treg Homeostasis |
Fecha de publicación: | may-2016 | Editor: | Elsevier | Citación: | Clinical Microbiology and Infection 22(5): 461.e1-461.e5 (2016) | Resumen: | Regulatory T (Treg) cells comprise different functional subsets with different CCR5 expression. Treg homeostasis is disrupted by HIV but the effect of treatment has barely been explored. In a longitudinal design, we compared the effect of a maraviroc-containing (n = 9) or sparing (n = 12) therapy in antiretroviral-naive HIV-positive participants on peripheral FoxP3low CD45RA+ (nTreg), FoxP3high CD45RA– (eTreg) and FoxP3low CD45RA– (non-Treg) cells. Maraviroc significantly reduced all subsets in the short-term and, except for nTreg cells, also normalized them in the long-term. The correlation between eTreg cells and CD4 counts, lost before treatment, was only restored by maraviroc. The differential effect of maraviroc on Treg subsets contributes to understanding its immunomodulatory effects. | Versión del editor: | http://dx.doi.org/10.1016/j.cmi.2015.12.025 | URI: | http://hdl.handle.net/10261/200052 | DOI: | 10.1016/j.cmi.2015.12.025 | Identificadores: | doi: 10.1016/j.cmi.2015.12.025 e-issn: 1469-0691 issn: 1198-743X |
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