Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/199985
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Altered oscillatory dynamics of CA1 parvalbumin basket cells during theta-gamma rhythmopathies of temporal lobe epilepsy |
Autor: | López-Pigozzi, Diego; Laurent, François CSIC; Brotons-Mas, Jorge R. CSIC ORCID; Valderrama, Mario; Valero, Manuel CSIC ORCID; Fernández-Lamo, Iván CSIC; Cid Ledesma, Elena CSIC ORCID; Gómez-Domínguez, Daniel CSIC ORCID; Gal, Beatriz CSIC ORCID; Menéndez de la Prida, Liset CSIC ORCID | Palabras clave: | Episodic memory Hippocampus Silicon probes Tetrodes Theta-gamma |
Fecha de publicación: | 2016 | Editor: | Society for Neuroscience | Citación: | eNeuro 3(6): 1-20 (2016) | Resumen: | Recent reports in human demonstrate a role of theta–gamma coupling in memory for spatial episodes and a lack of coupling in people experiencing temporal lobe epilepsy, but the mechanisms are unknown. Using multisite silicon probe recordings of epileptic rats engaged in episodic-like object recognition tasks, we sought to evaluate the role of theta–gamma coupling in the absence of epileptiform activities. Our data reveal a specific association between theta–gamma (30–60 Hz) coupling at the proximal stratum radiatum of CA1 and spatial memory deficits. We targeted the microcircuit mechanisms with a novel approach to identify putative interneuronal types in tetrode recordings (parvalbumin basket cells in particular) and validated classification criteria in the epileptic context with neurochemical identification of intracellularly recorded cells. In epileptic rats, putative parvalbumin basket cells fired poorly modulated at the falling theta phase, consistent with weaker inputs from Schaffer collaterals and attenuated gamma oscillations, as evaluated by theta-phase decomposition of current–source density signals. We propose that theta–gamma interneuronal rhythmopathies of the temporal lobe are intimately related to episodic memory dysfunction in this condition. | Descripción: | © 2016 Lopez-Pigozzi et al. | Versión del editor: | http://dx.doi.org/10.1523/ENEURO.0284-16.2016 | URI: | http://hdl.handle.net/10261/199985 | DOI: | 10.1523/ENEURO.0284-16.2016 | E-ISSN: | 2373-2822 |
Aparece en las colecciones: | (IC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Lopez_Pigozzi_Altered_Art2016.pdf | 4,17 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
23
checked on 15-abr-2024
SCOPUSTM
Citations
42
checked on 15-abr-2024
WEB OF SCIENCETM
Citations
34
checked on 26-ene-2024
Page view(s)
169
checked on 21-abr-2024
Download(s)
110
checked on 21-abr-2024