English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/199653
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Lack of sterol regulatory element binding factor-1c imposes glial fatty acid utilization leading to peripheral neuropathy

AuthorsCermenati, G.; Audano, Matteo; Giatti, S.; Carozzi, V.; Porretta-Serapiglia, Carla; Pettinato, Emanuela; Ferri, Cinzia; D’Antonio, Maurizio; Fabiani, Emma De; Crestani, M.; Scurati, Samuele; Saez, Enrique; Azcoitia, Íñigo; Cavaletti, G.; García-Segura, Luis M. ; Melcangi, R. C.; Caruso, Donatella; Mitro, Nico
Issue Date7-Apr-2015
PublisherElsevier BV
CitationCell Metabolism 21(4): 571-583 (2015)
AbstractMyelin is a membrane characterized by high lipid content to facilitate impulse propagation. Changes in myelin fatty acid (FA) composition have been associated with peripheral neuropathy, but the specific role of peripheral nerve FA synthesis in myelin formation and function is poorly understood. We have found that mice lacking sterol regulatory element-binding factor-1c (Srebf1c) have blunted peripheral nerve FA synthesis that results in development of peripheral neuropathy. Srebf1c-null mice develop Remak bundle alterations and hypermyelination of small-caliber fibers that impair nerve function. Peripheral nerves lacking Srebf1c show decreased FA synthesis and glycolytic flux, but increased FA catabolism and mitochondrial function. These metabolic alterations are the result of local accumulation of two endogenous peroxisome proliferator-activated receptor-α (Pparα) ligands, 1-palmitoyl-2-oleyl-sn-glycerol-3-phosphatidylcholine and 1-stearoyl-2-oleyl-sn-glycerol-3-phosphatidylcholine. Treatment with a Pparα antagonist rescues the neuropathy of Srebf1c-null mice. These findings reveal the importance of peripheral nerve FA synthesis to sustain myelin structure and function.
Publisher version (URL)http://dx.doi.org/10.1016/j.cmet.2015.02.016
Appears in Collections:(IC) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.