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Bimodal Nd-Doped LuVO4 Nanoprobes Functionalized with Polyacrilic Acid for X-Ray Computed Tomography and NIR Luminescent Imaging

AuthorsNúñez, Nuria O. ; Cussó, Fernando; Cantelar, Eugenio; Martín-García, Beatriz; Fuente, Jesús M. de la; Corral, Ariadna; Balcerzyk, Marcine; Ocaña, Manuel
Polyacrilic acid
NIR luminescence
X-ray computed tomography
Issue Date2020
PublisherMultidisciplinary Digital Publishing Institute
CitationNanomaterials, 10:149 (2020)
AbstractUniform Nd3+-doped LuVO4 nanophosphors have been synthesized for the first time in literature by using a poliol-basedmethod at 120 C fromNd3+ and vanadate precursors. After optimizing the Nd doping level, these phosphors present intense luminescence in the near-infrared biological windows. The X-ray attenuation capacity of the optimum nanophosphor has been found to be higher than that of a commercial X-ray computed tomography contrast agent. After surface coating with polyacrylic acid, such nanoparticles present high colloidal stability in physiological pHmediumand high cell viability. Because of these properties, the developedNd3+-doped LuVO4 nanoparticles have potential applications as a bimodal probe for NIR luminescent bioimaging and X-ray computed tomography
Publisher version (URL)http://dx.doi.org/10.3390/nano10010149
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