Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/199405
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | An intergenic regulatory region mediates Drosophila Myc-induced apoptosis and blocks tissue hyperplasia |
Autor: | Zhang, S.; Casas-Tinto, Sergio CSIC ORCID; Li, G.; Lin, N,; Chung, M.; Moreno, E. CSIC; Moberg, K. H.; Zhou, L. | Fecha de publicación: | 2015 | Editor: | Springer Nature | Citación: | Oncogene 34: 2385-2397 (2015) | Resumen: | Induction of cell-autonomous apoptosis following oncogene-induced overproliferation is a major tumor-suppressive mechanism in vertebrates. However, the detailed mechanism mediating this process remains enigmatic. In this study, we demonstrate that dMyc-induced cell-autonomous apoptosis in the fruit fly Drosophila melanogaster relies on an intergenic sequence termed the IRER (irradiation-responsive enhancer region). The IRER mediates the expression of surrounding proapoptotic genes, and we use an in vivo reporter of the IRER chromatin state to gather evidence that epigenetic control of DNA accessibility within the IRER is an important determinant of the strength of this response to excess dMyc. In a previous work, we showed that the IRER also mediates P53-dependent induction of proapoptotic genes following DNA damage, and the chromatin conformation within IRER is regulated by polycomb group-mediated histone modifications. dMyc-induced apoptosis and the P53-mediated DNA damage response thus overlap in a requirement for the IRER. The epigenetic mechanisms controlling IRER accessibility appear to set thresholds for the P53- and dMyc-induced expression of apoptotic genes in vivo and may have a profound impact on cellular sensitivity to oncogene-induced stress. | Versión del editor: | http://dx.doi.org/10.1038/onc.2014.160 | URI: | http://hdl.handle.net/10261/199405 | DOI: | 10.1038/onc.2014.160 | ISSN: | 0950-9232 | E-ISSN: | 1476-5594 |
Aparece en las colecciones: | (IC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
10
checked on 19-abr-2024
SCOPUSTM
Citations
16
checked on 13-abr-2024
WEB OF SCIENCETM
Citations
13
checked on 25-feb-2024
Page view(s)
191
checked on 19-abr-2024
Download(s)
29
checked on 19-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.