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Clusters of patients with candidaemia due to genotypes of Candida albicans and Candida parapsilosis: Differences in frequency between hospitals

AuthorsMarcos-Zambrano, L.J.; Escribano, P.; Sanguinetti, M.; Gómez G. de la Pedrosa, E.; Carolis de, E.; Vella, A.; Cantón, Rafael; Bouza, E.; Guinea, J.
KeywordsCandida albicans
Candida parapsilosis
Issue DateJul-2015
CitationClinical Microbiology and Infection 21(7): 677-683 (2015)
AbstractThe presence of clusters (identical genotypes infecting different patients) suggests patient-to-patient transmission or a common source for strains. We report the results of a genotyping study based on microsatellite markers of Candida albicans (n = 179) and Candida parapsilosis (n = 76) causing candidaemia, to assess and compare the percentage of patients grouped in clusters during the study period (January 2010 to December 2012). The study was performed in two large tertiary hospitals in Madrid, Spain. We detected 145 C. albicans genotypes (21 in clusters) and 63 C. parapsilosis genotypes (seven in clusters). Clusters involved two to seven patients each. Most of the clusters in the two centres involved two patients for both species, but the number of patients included in each cluster differed between hospitals. Considering both species, the percentage of patients per cluster ranged from 19% to 38% (p < 0.05) in Hospital A and B respectively. Up to 2.9% of genotypes were present in both hospitals. Clusters of C. albicans and C. parapsilosis genotypes causing candidaemia differed between hospitals, suggesting differences in strain transmission. Occasionally, the same genotypes were found in patients admitted to different hospitals located in the same city.
Publisher version (URL)http://dx.doi.org/10.1016/j.cmi.2015.03.007
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