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http://hdl.handle.net/10261/198708
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Palacios, Carmen | - |
dc.contributor.author | Yerbes, Rosario | - |
dc.contributor.author | López-Rivas, Abelardo | - |
dc.date.accessioned | 2020-01-23T08:35:35Z | - |
dc.date.available | 2020-01-23T08:35:35Z | - |
dc.date.issued | 2006 | - |
dc.identifier | doi: 10.1158/0008-5472.CAN-06-0808 | - |
dc.identifier | issn: 0008-5472 | - |
dc.identifier | e-issn: 1538-7445 | - |
dc.identifier.citation | Cancer Research 66(17): 8858-8869 (2006) | - |
dc.identifier.uri | http://hdl.handle.net/10261/198708 | - |
dc.description.abstract | The cyclin-dependent kinase inhibitor flavopiridol is undergoing clinical trials as an antitumor drug. We show here that pretreatment of different human breast cancer cell lines with flavopiridol facilitates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. In breast tumor cells, apoptosis induction by TRAIL is blocked at the level of apical caspase-8 activation. Flavopiridol treatment enhances TRAIL-induced formation of death-inducing signaling complex and early processing of procaspase-8. Subsequently, a TRAIL-induced, mitochondria-operated pathway of apoptosis is activated in cells treated with flavopiridol. Down-regulation of cellular FLICE-inhibitory proteins (c-FLIP; c-FLIPL and C-FLIPS) is observed on flavopiridol treatment. c-FLIP loss and apoptosis sensitization by flavopiridol are both prevented in cells treated with an inhibitor of the ubiquitin-proteasome system. Furthermore, targeting c-FLIP directly with small interfering RNA oligonucleotides also sensitizes various human breast tumor cell lines to TRAIL-induced apoptosis. Our results indicate that flavopiridol sensitizes breast cancer cells to TRAIL-induced apoptosis by facilitating early events in the apoptotic pathway, and this combination treatment could be regarded as a potential therapeutic tool against breast tumors. | - |
dc.description.sponsorship | Ministerio de Educación y Ciencia grant SAF-2003-00402 and Association for International Cancer Research (AICR) grant AICR-03-031 (A. López-Rivas), AICR contract (C. Palacios), and Junta de Andalucía and Ministerio de Educación y Ciencia contract (R. Yerbes). | - |
dc.language | eng | - |
dc.publisher | American Association for Cancer Research | - |
dc.rights | closedAccess | - |
dc.title | Flavopiridol induces cellular FLICE-inhibitory protein degradation by the proteasome and promotes TRAIL-induced early signaling and apoptosis in breast tumor cells | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1158/0008-5472.CAN-06-0808 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1158/0008-5472.CAN-06-0808 | - |
dc.date.updated | 2020-01-23T08:35:35Z | - |
dc.contributor.funder | Ministerio de Educación y Ciencia (España) | - |
dc.contributor.funder | Junta de Andalucía | - |
dc.contributor.funder | Association for International Cancer Research | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/100004435 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011011 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
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