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Title

Itraconazole and thiophanate-methyl fail to clear tadpoles naturally infected with the hypervirulent lineage of Batrachochytrium dendrobatidis

AuthorsFernández-Loras, Andrés; Martín-Beyer, Bárbara; Garner, Trenton W. J.; Bosch, Jaime
KeywordsItraconazole
Thiophanate-methyl
Alytes obstetricans
Chytridiomycosis
Issue Date16-Oct-2018
PublisherInter Research
CitationDiseases of Aquatic Organisms 131: 73-78 (2018)
AbstractThe emerging infectious disease chytridiomycosis, caused by the fungus Batrachochytrium dendrobatidis, is a major driver pushing many amphibian species to the brink of extinction. Substantial efforts to develop effective protocols that use antifungal drugs have had notable success. Here, we used the antifungal agents itraconazole and thiophanate-methyl, singly and in combination, in an attempt to treat common midwife toad Alytes obstetricans larvae naturally infected with the globalized hypervirulent lineage of B. dendrobatidis. Despite the successful use of itraconazole in a closely related species (A. muletensis), our results show that these antifungal treatments are not always effective and that full clearance of animals cannot be assumed following treatment.
Publisher version (URL)https://doi.org/10.3354/dao03282
URIhttp://hdl.handle.net/10261/197058
DOI10.3354/dao03282
ISSN0177-5103
E-ISSN1616-1580
Appears in Collections:(MNCN) Artículos
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