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Title: β-Lactams derived from phenylalanine and homologues: effects of the distance between the aromatic rings and the α-stereogenic reactive center on the memory of chirality
Authors: Bonache de Marcos, María Ángeles, Cativiela, Carlos, García-López, María Teresa, González-Muñiz, Rosario
Issue Date: Aug-2006
Publisher: Elsevier
Abstract: The enantioselectivity in the base-promoted cyclization of N-chloroacetyl derivatives of Phe, Phg, and Hph is dependent on the side-chain length, with the best results for Phg analogues (up to 74% ee). In contrast, shortening of the N-substituent, from a (p-methoxy)benzyl group to a (p-methoxy)phenyl moiety, led to a decrease in selectivity.
Description: 5 pages, 1 table, 2 schemes.
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ISSN: 0040-4039
???metadata.dc.identifier.doi???: 10.1016/j.tetlet.2006.06.057
Citation: Tetrahedron Letters 47(··): 5883-5887 (2006)
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