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Título : β-Lactams derived from phenylalanine and homologues: effects of the distance between the aromatic rings and the α-stereogenic reactive center on the memory of chirality
Autor : Bonache de Marcos, María Ángeles, Cativiela, Carlos, García-López, María Teresa, González-Muñiz, Rosario
Fecha de publicación : Aug-2006
Editor: Elsevier
Citación : Tetrahedron Letters 47(··): 5883-5887 (2006)
Resumen: The enantioselectivity in the base-promoted cyclization of N-chloroacetyl derivatives of Phe, Phg, and Hph is dependent on the side-chain length, with the best results for Phg analogues (up to 74% ee). In contrast, shortening of the N-substituent, from a (p-methoxy)benzyl group to a (p-methoxy)phenyl moiety, led to a decrease in selectivity.
Descripción : 5 pages, 1 table, 2 schemes.
Versión del editor:
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2006.06.057
Citación : Tetrahedron Letters 47(··): 5883-5887 (2006)
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