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dc.contributor.authorMarín-Royo, Gemaes_ES
dc.contributor.authorOrtega-Hernández, Adrianaes_ES
dc.contributor.authorMartínez-Martínez, Ernestoes_ES
dc.contributor.authorJurado-López, Raqueles_ES
dc.contributor.authorLuaces, Maríaes_ES
dc.contributor.authorIslas, Fabiánes_ES
dc.contributor.authorGómez-Garre, Dulcenombrees_ES
dc.contributor.authorDelgado-Valero, Beatrizes_ES
dc.contributor.authorLagunas, Estheres_ES
dc.contributor.authorRamchandani, Buntyes_ES
dc.contributor.authorGarcía-Bouza, Mónicaes_ES
dc.contributor.authorNieto, María Luisaes_ES
dc.contributor.authorCachofeiro, Victoriaes_ES
dc.identifier.citationScientific Reports 9: 444 (2019)es_ES
dc.description.abstractCardiac lipotoxicity is involved in the cardiac functional consequences associated with obesity. Therefore, the aim of this study was to explore whether changes in the mitochondrial lipid cardiac profile could reflect differences in cardiac function and structure in obese and non-obese rats with myocardial infarction (MI). Whether these changes can also be reflected in a specific plasma miRNA signature as markers of cardiac damage was also evaluated. Rats were fed with either standard (3.5% fat) or high fat diet (35% fat) for 6 weeks before the induction of MI and sacrificed 4 weeks later. MI showed cardiac lipotoxicity independently of the presence of obesity, although obese and non-obese rats did not present the same cardiac lipid profile at mitochondrial level. Several cardiac lipid species in mitochondria, including cardiolipins and triglycerides, were associated with myocardial fibrosis, with mitochondrial triglyceride levels being independently associated with it; this supports that lipotoxicity can affect cardiac function. MI down-regulated plasma levels of miRNA 15b-5p and 194-5p in obese and non-obese animals, which were associated with cardiac function, mitochondrial lipids and myocardial fibrosis, with miRNA 15b-5p levels being independently associated with cardiac fibrosis. This could support that lipotoxicity could affect heart function by modulating plasma miRNAs.es_ES
dc.description.sponsorshipThis work was supported by Instituto de Salud Carlos III-FondoEuropeo de Desarrollo Regional (FEDER) (PI15/01060; CIBERCV) a way to build Europe, Ministerio de Economia y Competitividad (SAF2016-81063) and from the Sociedad Española de Cardiología (Basic Research in Cardiology 2016). EMM was supported by a contract from CAM (Atracción de talento).es_ES
dc.publisherSpringer Naturees_ES
dc.relation.isversionofPublisher's versiones_ES
dc.titleThe impact of cardiac lipotoxicity on cardiac function and mirnas signature in obese and non-obese rats with myocardial infarctiones_ES
dc.description.peerreviewedPeer reviewedes_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderSociedad Española de Cardiologíaes_ES
dc.contributor.funderComunidad de Madrides_ES
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