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Effects of combined d-fagomine and omega-3 PUFAs on gut microbiota subpopulations and diabetes risk factors in rats fed a high-fat diet

AuthorsHereu, Mercè; Ramos-Romero, Sara; Busquets, Cristina; Atienza, Lidia; Amézqueta, Susana; Miralles-Pérez, Bernat; Nogués, M. R.; Méndez, Lucía ; Medina, Isabel ; Torres, Josep Lluís
Issue Date2019
PublisherNature Publishing Group
CitationScientific Reports 9: 16628 (2019)
AbstractFood contains bioactive compounds that may prevent changes in gut microbiota associated with Westernized diets. The aim of this study is to explore the possible additive effects of d-fagomine and ω-3 PUFAs (EPA/DHA 1:1) on gut microbiota and related risk factors during early stages in the development of fat-induced pre-diabetes. Male Sprague Dawley (SD) rats were fed a standard diet, or a high-fat (HF) diet supplemented with d-fagomine, EPA/DHA 1:1, a combination of both, or neither, for 24 weeks. The variables measured were fasting glucose and glucose tolerance, plasma insulin, liver inflammation, fecal/cecal gut bacterial subgroups and short-chain fatty acids (SCFAs). The animals supplemented with d-fagomine alone and in combination with ω-3 PUFAs accumulated less fat than those in the nonsupplemented HF group and those given only ω-3 PUFAs. The combined supplements attenuated the high-fat-induced incipient insulin resistance (IR), and liver inflammation, while increasing the cecal content, the Bacteroidetes:Firmicutes ratio and the populations of Bifidobacteriales. The functional effects of the combination of d-fagomine and EPA/DHA 1:1 against gut dysbiosis and the very early metabolic alterations induced by a high-fat diet are mainly those of d-fagomine complemented by the anti-inflammatory action of ω-3 PUFAs
Description12 pages, 4 tables, 5 figures.-- This article is licensed under a Creative Commons Attribution 4.0 International License,
Publisher version (URL)https://doi.org/10.1038/s41598-019-52678-5
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