Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/195696
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | CD3 epsilon recruits Numb to promote TCR degradation |
Autor: | Martín-Blanco, Nadia M.; Jiménez Teja, Daniel; Bretones, Gabriel CSIC ORCID; Borroto Revuelta, Aldo; Caraballo, Michael; Screpanti, I.; Leon, Javier; Alarcón, Balbino CSIC ORCID; Cañelles, Matilde CSIC ORCID | Palabras clave: | lymphocyte signaling T-cell activation T-cell differentiation T-cell receptor |
Fecha de publicación: | mar-2016 | Editor: | Oxford University Press | Citación: | International Immunology | Resumen: | Modulation of TCR signaling upon ligand binding is achieved by changes in the equilibrium between TCR degradation, recycling and synthesis; surprisingly, the molecular mechanism of such an important process is not fully understood. Here, we describe the role of a new player in the mediation of TCR degradation: the endocytic adaptor Numb. Our data show that Numb inhibition leads to abnormal intracellular distribution and defective TCR degradation in mature T lymphocytes. In addition, we find that Numb simultaneously binds to both Cbl and a site within CD3 epsilon that overlaps with the Nck binding site. As a result, Cbl couples specifically to the CD3 epsilon chain to mediate TCR degradation. The present study unveils a novel role of Numb that lies at the heart of TCR signaling initiation and termination. | URI: | http://hdl.handle.net/10261/195696 | DOI: | 10.1093/intimm/dxv060 | ISSN: | 0953-8178 | E-ISSN: | 1460-2377 |
Aparece en las colecciones: | (IPBLN) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,35 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
5
checked on 14-mar-2024
SCOPUSTM
Citations
6
checked on 12-mar-2024
WEB OF SCIENCETM
Citations
7
checked on 27-feb-2024
Page view(s)
201
checked on 18-mar-2024
Download(s)
25
checked on 18-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.