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Title

Encapsulation of upconversion nanoparticles in periodic mesoporous organosilicas

AuthorsRahmani, Saher; Mauriello Jimenez, Chiara; Aggad, Dina; González-Mancebo, Daniel; Ocaña, Manuel ; M. A. Ali, Lamiaa; Nguyen, Christophe; Becerro, Ana Isabel ; Francolon, Nadège; Oliveiro, Erwan; Boyer, Damien; Mahiou, Rachid; Raehm, Laurence; Gary-Bobo, Magali; Durand, Jean-Olivier; Charnay, Clarence
KeywordsUpconversion
Periodic mesoporous organosilica nanoparticles
Cancer
Issue Date9-Nov-2019
PublisherMultidisciplinary Digital Publishing Institute
CitationMolecules 24(22): 4054 (2019)
Abstract1) Background: Nanomedicine has recently emerged as a promising field, particularly for cancer theranostics. In this context, nanoparticles designed for imaging and therapeutic applications are of interest. We, therefore, studied the encapsulation of upconverting nanoparticles in mesoporous organosilica nanoparticles. Indeed, mesoporous organosilica nanoparticles have been shown to be very efficient for drug delivery, and upconverting nanoparticles are interesting for near-infrared and X-ray computed tomography imaging, depending on the matrix used. (2) Methods: Two different upconverting-based nanoparticles were synthesized with Yb3+-Er3+ as the upconverting system and NaYF4 or BaLuF5 as the matrix. The encapsulation of these nanoparticles was studied through the sol-gel procedure with bis(triethoxysilyl)ethylene and bis(triethoxysilyl)ethane in the presence of CTAB. (3) Results: with bis(triethoxysilyl)ethylene, BaLuF5: Yb3+-Er3+, nanoparticles were not encapsulated, but anchored on the surface of the obtained mesoporous nanorods BaLuF5: Yb3+-Er3+@Ethylene. With bis(triethoxysilyl)ethane, BaLuF5: Yb3+-Er3+ and NaYF4: Yb3+-Er3+nanoparticles were encapsulated in the mesoporous cubic structure leading to BaLuF5: Yb3+-Er3+@Ethane and NaYF4: Yb3+-Er3+@Ethane, respectively. (4) Conclusions: upconversion nanoparticles were located on the surface of mesoporous nanorods obtained by hydrolysis polycondensation of bis(triethoxysilyl)ethylene, whereas encapsulation occurred with bis(triethoxysilyl)ethane. The later nanoparticles NaYF4: Yb3+-Er3+@Ethane or BaLuF5: Yb3+-Er3+@Ethane were promising for applications with cancer cell imaging or X-ray-computed tomography respectively.
Publisher version (URL)https://doi.org/10.3390/molecules24224054
URIhttp://hdl.handle.net/10261/195368
DOI10.3390/molecules24224054
E-ISSN1420-3049
Appears in Collections:(ICMS) Artículos
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