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Title

Combined buckwheat d-Fagomine and fish Omega-3 PUFAs stabilize the populations of gut prevotella and bacteroides while reducing weight gain in rats

AuthorsHereu, Mercè; Ramos-Romero, Sara; Marín-Valls, Roser; Amézqueta, Susana; Miralles-Pérez, Bernat; Romeu, Marta; Méndez, Lucía ; Medina, Isabel ; Torres, Josep Lluís
KeywordsWeight
gut microbiota
Prevotella
Bacteroides
d-fagomine
iminosugar
iminocyclitol
ω-3 PUFAs
Issue Date31-Oct-2019
PublisherMultidisciplinary Digital Publishing Institute
CitationNutrients 11(11): 2606 (2019)
AbstractSome functional food components may help maintain homeostasis by promoting balanced gut microbiota. Here, we explore the possible complementary effects of d-fagomine and ω-3 polyunsaturated fatty acids (ω-3 PUFAs) eicosapentaenoic acid/docosahexaenoic acid (EPA/DHA 1:1) on putatively beneficial gut bacterial strains. Male Sprague–Dawley rats were supplemented with d-fagomine, ω-3 PUFAs, or both, for 23 weeks. Bacterial subgroups were evaluated in fecal DNA by quantitative real-time polymerase chain reaction (qRT-PCR) and short-chain fatty acids were determined by gas chromatography. We found that the populations of the genus Prevotella remained stable over time in animals supplemented with d-fagomine, independently of ω-3 PUFA supplementation. Animals in these groups gained less weight than controls and rats given only ω-3 PUFAs. d-Fagomine supplementation together with ω-3 PUFAs maintained the relative populations of Bacteroides. ω-3 PUFAs alone or combined with d-fagomine reduced the amount of acetic acid and total short-chain fatty acids in feces. The plasma levels of pro-inflammatory arachidonic acid derived metabolites, triglycerides and cholesterol were lower in both groups supplemented with ω-3 PUFAs. The d-fagomine and ω-3 PUFAs combination provided the functional benefits of each supplement. Notably, it helped stabilize populations of Prevotella in the rat intestinal tract while reducing weight gain and providing the anti-inflammatory and cardiovascular benefits of ω-3 PUFAs.
Publisher version (URL)https://doi.org/10.3390/nu11112606
URIhttp://hdl.handle.net/10261/195356
DOI10.3390/nu11112606
E-ISSN2072-6643
Appears in Collections:(IIM) Artículos
(IQAC) Artículos
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