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Título

A Phage Protein Aids Bacterial Symbionts in Eukaryote Immune Evasion

AutorJahn, Martin T.; Arkhipova, Ksenia; Markert, Sebastian M.; Stigloher, Christian; Lachnit, Tim; Pita, Lucía CSIC ORCID ; Kupczok, Anne; Ribes, Marta CSIC ORCID ; Stengel, Stephanie T.; Rosenstiel, Philip C.; Dutilh, Bas E.; Hentschel, Ute
Palabras claveAnkyrin
Phage
Innate immunity
Immune evasion
Viromics
Community ecology
Symbiosis
Marine sponge
Fecha de publicaciónoct-2019
EditorElsevier
CitaciónCell Host and Microbe 26(4): 542-550 (2019)
ResumenPhages are increasingly recognized as important members of host-associated microbiomes, with a vast genomic diversity. The new frontier is to understand how phages may affect higher order processes, such as in the context of host-microbe interactions. Here, we use marine sponges as a model to investigate the interplay between phages, bacterial symbionts, and eukaryotic hosts. Using viral metagenomics, we find that sponges, although massively filtering seawater, harbor species-specific and even individually unique viral signatures that are taxonomically distinct from other environments. We further discover a symbiont phage-encoded ankyrin-domain-containing protein, which is widely spread in phages of many host-associated contexts including human. We confirm in macrophage infection assays that the ankyrin protein (ANKp) modulates the eukaryotic host immune response against bacteria. We predict that the role of ANKp in nature is to facilitate coexistence in the tripartite interplay between phages, symbionts, and sponges and possibly many other host-microbe associations
Descripción15 pages, 5 figures, 1 table, supplemental Information https://doi.org/10.1016/j.chom.2019.08.019
Versión del editorhttps://doi.org/10.1016/j.chom.2019.08.019
URIhttp://hdl.handle.net/10261/195317
DOI10.1016/j.chom.2019.08.019
Identificadoresdoi: 10.1016/j.chom.2019.08.019
issn: 1931-3128
e-issn: 1934-6069
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