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Title

A tracking algorithm for cell motility assays in CMOS systems

AuthorsMartínez-Gómez, C.; Olmo, Alberto; Huertas, Gloria ; Pérez, Pablo ; Maldonado-Jacobi, A.; Yúfera, A.
KeywordsElectrodes
Cancer
Two dimensional displays
Real-time systems
Fluorescence
Indexes
Sensors
Issue Date2017
PublisherInstitute of Electrical and Electronics Engineers
Citation39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (2017)
AbstractThis work proposes a method for the study and real-time monitoring of a single cell on a 2D electrode matrix, of great interest in cell motility assays and in the characterization of cancer cell metastasis. A CMOS system proposal for cell location based on occupation maps data generated from Electrical Cell-substrate Impedance Spectroscopy (ECIS) has been developed. From experimental assays data, an algorithm based on the analysis of the eight nearest neighbours has been implemented to find the cell center of mass. The path followed by a cell, proposing a Brownian route, has been simulated with the proposed algorithm. The presented results give an accuracy over 95% in the determination of the coordinates (x, y) from the expected cell center of mass.
Publisher version (URL)https://doi.org/10.1109/EMBC.2017.8036954
URIhttp://hdl.handle.net/10261/195212
DOIhttp://dx.doi.org/10.1109/EMBC.2017.8036954
ISBN978-1-5090-2810-8
ISSN1557-170X
E-ISSN1558-4615
Appears in Collections:(IMSE-CNM) Libros y partes de libros
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