English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/195129
Share/Impact:
Statistics
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging

AuthorsLópez-Noriega, Livia; Capilla-González, Vivian; Cobo-Vuilleumier, Nadia ; Martín-Vázquez, Eugenia; Lorenzo, Petra Isabel ; Martínez-Force, Enrique ; Soriano-Navarro, Mario; García-Fernández, María; Romero-Zerbo, Silvana Yanina; Bermúdez-Silva, Francisco Javier; Díaz-Contreras, Irene; Sánchez-Cuesta, Ana; Santos-Ocaña, Carlos ; Hmadcha, Abdelkrim ; Soria, Bernat; Martín, Franz ; Gauthier, Benoit R.; Martín-Montalvo, Alejandro
KeywordsLifespan
Healthspan
Thyroid hormones
Hyperthyroidism
Hypothyroidism
Glucose metabolism
Issue Date30-Sep-2019
PublisherImpact Journals
CitationAging 11 (18): 7746–7779 (2019)
AbstractAn inverse correlation between thyroid hormone levels and longevity has been reported in several species and reduced thyroid hormone levels have been proposed as a biomarker for healthy aging and metabolic fitness. However, hypothyroidism is a medical condition associated with compromised health and reduced life expectancy. Herein, we show, using wild-type and the Pax8 ablated model of hypothyroidism in mice, that hyperthyroidism and severe hypothyroidism are associated with an overall unhealthy status and shorter lifespan. Mild hypothyroid Pax8 +/- mice were heavier and displayed insulin resistance, hepatic steatosis and increased prevalence of liver cancer yet had normal lifespan. These pathophysiological conditions were precipitated by hepatic mitochondrial dysfunction and oxidative damage accumulation. These findings indicate that individuals carrying mutations on PAX8 may be susceptible to develop liver cancer and/or diabetes and raise concerns regarding the development of interventions aiming to modulate thyroid hormones to promote healthy aging or lifespan in mammals.
Description34 Páginas.-- 7 Figuras.-- 6 Figuras suplementarias.-- 4 Tablas suplementarias
Publisher version (URL)http://dx.doi.org/10.18632/aging.102285
URIhttp://hdl.handle.net/10261/195129
E-ISSN1945-4589
Appears in Collections:(CABIMER) Artículos
(IG) Artículos
Files in This Item:
File Description SizeFormat 
Aging_2019_V11_P7746.pdfArtículo principal7,95 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.